Job Description

The Vice President of Global Medical Affairs will provide strategic and hands-on leadership for Janux. Therapeutics. This role will be highly external-facing and execution-driven, responsible for shaping scientific narrative, building key external relationships, and ensuring high-quality, compliant medical engagement as Janux advances its clinical-stage oncology programs. The VP, Medical Affairs will report directly to the Chief Medical Officer, and partner closely with Clinical Development, Regulatory, Translational Science, and Commercial colleagues to ensure strong alignment between clinical strategy, external scientific exchange, and future commercialization readiness.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

• Build, lead, and execute the overall Medical Affairs strategy in alignment with Janux’s clinical development and corporate objectives.
• Establish scalable, compliant Medical Affairs infrastructure, processes, budgets, and operating models appropriate for a growing clinical-stage biotech organization.
• Serve as a key member of the cross-functional leadership team, providing medical and scientific insight to inform development and business decisions.
• Develop and oversee scientific and medical communications, including publications, congress strategy, scientific presentations, and medical information content.
• Shape and refine the clinical and scientific value across Janux’s oncology pipeline to ensure clear, accurate, and compelling external communication.
• Ensure consistency and scientific rigor across all external-facing medical materials and engagements.
• Build and maintain strong relationships with leading investigators, key opinion leaders, and other external experts in oncology and immunotherapy.
• Lead the planning and execution of advisory boards, investigator meetings, and scientific exchange activities.
• Represent Janux at major national and international scientific congresses and meetings through direct engagement and presentations.
• Partner closely with Clinical Development, Clinical Operations and Translational teams to provide medical input into protocol design, endpoint selection, and evidence generation strategies.
• Collaborate with Regulatory Affairs to ensure compliant scientific exchange and alignment with global regulatory standards.
• Support commercialization readiness by providing medical expertise for internal training, external education, and payer‑relevant evidence strategies.
• Demonstrated knowledge of implementing tools to optimize and expand reach and frequency of interactions with US providers, advocacy organizations, patients, and key partners.
• Direct knowledge of promotional regulatory processes, Fair Market Value (FMV) process, tiering, and alignment with third-party vendors.
• Ensure all Medical Affairs activities are conducted in accordance with FDA, ICH, and other applicable regulatory and compliance guidelines.
• Establish and maintain high-integrity processes for HCP and KOL interactions, publications, and scientific exchange.
• Available to travel and work independently as well as with other senior executives.

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS, AND ABILITIES

• Advanced degree required (MD, DO, PharmD, PhD, MS or equivalent).
• 15+ years (20 years preferred) of experience in Global Medical Affairs within biotech and/or pharmaceutical organizations, with increasing leadership responsibility.
• Significant experience in oncology required, including experience with immuno-oncology, cell therapy, or novel biologic platforms like T cell engagers.
• Demonstrated success in building and leading Global Medical Affairs functions in clinical-stage or emerging biotech environments.
• Proven track record in KOL engagement, scientific communications, and cross-functional collaboration.
• Strong understanding of Medical Affairs compliance, scientific standards, and regulatory requirements.
• Ability to operate effectively in a hands-on, fast-paced organization.

 Benefits:·              Annual bonus program·              Incentive stock option plan·              401k plan with flat non-elective employer contribution·              Comprehensive medical insurance with 90-100% employer-paid premiums·              Dental and vision insurance·              HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)·              Unlimited PTO·              Generous holiday schedule; includes summer and winter company shutdown·              Relocation assistance Schedule:·              Monday to Friday Work authorization:·              United States (Required) Additional Compensation:·              Annual targeted bonus % Work Location:·              Hybrid preferred in San Diego office. Remote permitted upon approval, with ability to travel up to 50% for meetings or site visits as required.   EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.