Ionis Pharmaceuticals, Inc.

Temp Senior Research Associate/Sr Scientist, Formulation and Delivery Sciences

Ionis Pharmaceuticals, Inc.  •  Carlsbad, CA (Remote)  •  10 hours ago
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Job Description

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

Temp Senior Research Associate/Sr Scientist, Formulation and Delivery Sciences

Hiring Manager: Bret Coldren

Location: Onsite - Carlsbad, CA

We seek an energetic and detail-oriented Sr. Research Associate or Sr. Scientist to support Ionis’s new gene editing franchise. This is an onsite laboratory-based role in nanoparticle formulations R&D for the intracellular delivery of RNA. The successful candidate will synthesize research scale RNA-loaded lipid nanoparticles, perform physical-chemical characterizations, and assist with biological testing in rodents and/or cell culture.

RESPONSIBILITIES:

  • Meticulous hands-on laboratory work synthesizing and documenting a variety of RNA-loaded lipid nanoparticles using microfluidic mixing, dialysis, filtration, centrifugation, SEC, etc.
  • Perform particle analysis via Ribogreen, DLS, zeta potential, pKa determination, etc and potentially analyze lipids and RNA via HPLC.
  • Assist with routine rodent procedures to dose formulations and assess safety/activity.
  • Thoroughly document results in electronic lab notebooks and assist with analysis of data.
  • Assist in maintaining general laboratory organization and supplies.

REQUIREMENTS:

  • BS in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 5 yrs of relevant academic/industry laboratory experience (for Sr. RA level)
  • PhD in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 2 years of relevant academic/industry laboratory experience (for Sr. Scientist role).
  • Must have prior expertise in accurately synthesizing numerous bench-scale RNA-containing LNP batches using microfluidic mixing technologies and bench-scale purification.
  • Must have prior experience performing nanoparticle characterization using Ribogreen, DLS, Zeta potential, etc. Experience with analysis of lipids/RNAs via HPLC is a big plus.
  • Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy)
  • A team player who can work both independently and with cross-functional teams in a fast-paced, entrepreneurial environment
  • Good organizational and written/verbal communication skills

For more information about Ionis and to apply for this position, please visit our website, http://www.ionis.com Reference Requisition # TEMP

The hourly pay scale for this position is $42.34/hour to $75.49/hour

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Ionis Pharmaceuticals, Inc.

About Ionis Pharmaceuticals, Inc.

For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis currently has five marketed medicines and a leading pipeline in neurology, cardiology, and other areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients.

Industry
Biotech & Life Sciences
Company Size
1,001-5,000 employees
Headquarters
Carlsbad, CA
Year Founded
1989
Website
ionis.com
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