Job Description

What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Lead Infrastructure Engineer – Cambridge

Hybrid working, 2–3 days per week in the office

We have a new exciting opportunity for a hands-on technical Senior Infrastructure Lead to join our Enterprise Infrastructure team at our EMEALA Regional Head Quarters, where you'll be accountable for the stability, security, and continuous improvement of enterprise infrastructure, identity, end user computing, and data centre services.

This role combines strong engineering depth with technical leadership, acting as a senior escalation point for complex issues, driving infrastructure standards, and delivering practical improvements that strengthen service resilience and employee productivity.

Illumina's employee benefits are industry-leading and include, flexible time off, private medical insurance, compassion and care time off, leisure travel insurance, pension, employee stock purchasing program, volunteer time off, and much more!

Why You

You are a highly capable infrastructure engineer with strong hands-on expertise across enterprise platforms and you have the credibility to lead technically in a complex global environment.

You bring deep knowledge of Windows Server, virtualization, cloud, identity, and endpoint technologies, and you are comfortable owning complex issues from diagnosis through to resolution.

You combine strong troubleshooting skills with sound technical judgment, clear communication, and a practical approach to improving reliability, security, and operational effectiveness.

Technical Skills & Experience requirements

• Strong hands-on expertise across enterprise infrastructure, including Windows Server, Active Directory, Azure AD, virtualization, storage, backup and recovery, and core data centre operations.
• Strong experience with endpoint engineering and management, including Intune, SCCM, Jamf, Windows and macOS lifecycle management, endpoint security, patching, and software deployment.
• Solid technical capability across Microsoft 365, Azure infrastructure services, Okta, SSO, MFA, conditional access, and enterprise authentication troubleshooting.
• Proven ability to troubleshoot complex cross-platform issues, lead root cause analysis, and improve operational efficiency through scripting, automation, and clear technical documentation.

Key Responsibilities

• Lead the design, implementation, support, and continuous improvement of enterprise infrastructure across on-premises and cloud environments.
• Act as a senior escalation point for complex infrastructure, identity, and endpoint issues, leading root cause analysis and permanent resolution.
• Own infrastructure lifecycle activities including deployment, upgrades, patching, hardware refresh, capacity planning, and decommissioning.
• Maintain secure, stable, and compliant infrastructure and endpoint services aligned with enterprise standards.
• Lead and improve core enterprise services including Active Directory, Azure AD, Okta, SSO, MFA, and endpoint management platforms.
• Strengthen resilience through effective backup, recovery, documentation, automation, and operational standardization.
• Partner across Service Desk, EUC, security, and application teams to resolve issues, deliver improvements, and support global operations.
• Participate in a 24x7 Tier 2 on-call rotation supporting critical infrastructure and end user computing services.

The estimated base salary range for the Staff IT Engineer role based in United Kingdom is GBP 63,800 - 95,600.
The range reflects long‑term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. This salary range applies to the primary posting location listed above. Should the level or location of the role change during the hiring process, the applicable base pay range will be updated accordingly. Compensation ranges for other locations will differ to reflect local market competitiveness and will be shared with candidates if applicable during the recruitment process.
Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package.
We offer a thoughtfully designed benefits package that supports your wellbeing, flexibility, and life beyond work—combining globally differentiated offerings with locally tailored programs. This includes support during important life moments, flexible time off, opportunities to give back, and a weeklong company-wide summer shutdown. In the UK, we also offer flexible benefits, a company contribution of 10% into your pension, and private medical insurance, alongside additional benefits to support you and your family.
We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.