OneOncology is positioning community oncologists to drive the future of medical care through a patient-centric, physician-driven, and technology-powered model to help improve the lives of everyone living with cancer and other diseases. Our team is bringing together leaders to the market place to help drive OneOncology’s mission and vision.
Why join us? This is an exciting time to join OneOncology. Our values-driven culture reflects our startup enthusiasm supported by industry leaders in oncology, urology, technology, and finance. We are looking for talented and highly-motivated individuals who demonstrate a natural desire to improve and build new processes that support the meaningful work of independent physicians and the patients they serve.
We are seeking a Senior AI Engineer to lead the design, development, and production deployment of advanced AI systems on Azure and Databricks, reporting to the Manager, Software Engineering & AI. You will own the technical direction for agentic AI platforms, Retrieval Augmented Generation (RAG) architectures, and large-scale model training and serving across the organization. This is a senior individual-contributor role with significant architectural authority: you will set standards, mentor engineers, partner closely with product and clinical stakeholders, and be accountable for the reliability, cost, and clinical safety of the AI systems you deliver. Success in this role requires deep machine learningexpertise, proven production experience on Azure and Databricks, and strong judgment to make sound trade-offs in a regulated healthcare environment.
Responsibilities
Architect and lead end-to-end agentic AI systems enabling autonomous decision-making, multi-step planning, and tool use; design planning, reasoning, memory, and orchestration layers with strong evaluation, observability, and guardrails
Drive performance, safety, and cost optimization for agentsoperatingin complex, dynamic environments
Own production RAG architecture across structured and unstructured oncology data;optimizefor retrieval quality, latency, and grounding
Design scalable indexing, hybrid retrieval strategies, and evaluation frameworks; lead fine-tuning, adapters, and prompt engineering to improve LLM performance
Lead training and deployment of LLMs and deep learning models on Azure ML and Databricks, including distributed GPU training
Define scalable data preprocessing, feature engineering, and labeling pipelines; drive optimization across hyperparameters, architecture, quantization, and serving
Own full model lifecycle: versioning, evaluation, monitoring, drift detection, and retraining
Set technical direction for AI workloads across Azure and Databricks; design secure, scalable, HIPAA-compliant data and ML pipelines
Establish standards for cost, performance, reliability, and capacity planning, including FinOps for AI infrastructure
Define and enforceMLOpspractices including CI/CD, automated evaluation, A/B testing, canary deployments, and incident response
Build reusable platform tooling to accelerate safe and efficient AI feature delivery
Mentor engineers, lead design reviews, and elevate code quality and evaluation rigor
Collaborate cross-functionally to deliver AI solutions aligned with clinical and business outcomes
Translate ambiguity into clear technical roadmaps and communicate trade-offs to executive, technical, and clinical stakeholders
Shape organizational AI strategy, standards, and responsible AI practices
Evaluate emerging models and techniques, driving adoption where valuable
Represent the organization in industry forums, conferences, and partner engagements
Additionalresponsibilitiesasassigned to help drive our mission of improving the lives of everyone living with cancer.
Requiredor PreferredQualifications(specify within)
Bachelor’s orMaster’s in Computer Science, AI, or related field (or equivalent experience)
7+ years software/ML engineering, including 3+ years building and operating production ML/LLM systems
Proventrack recorddelivering AI/ML systems from prototype to scaled production
Deepexpertisein LLMs, transformers, fine-tuning, and inference optimization
Expert Python; strong foundations in distributed systems, data engineering, and software design
Required experience with Azure and Databricks (Azure ML, Databricks workflows,MLflow, Spark pipelines)
Hands-on experience with vector databases (e.g., Azure AI Search, Databricks Vector Search,pgvector, FAISS) and RAG patterns
Experience with LLM orchestration and agent frameworks (e.g.,LangChain,LlamaIndex, Semantic Kernel)
Strong evaluation practices (offline/online evals, golden datasets, quality metrics for LLM/agent systems)
Excellent problem-solving, communication, and cross-functional collaboration skills
Preferred:
Experience designing and shipping agentic AI systems in production.
Experience implementing RAG over regulated or sensitive data (healthcare, finance, legal).
Experience withMLOpstooling and platform engineering for AI (model registries, feature stores, serving infrastructure, observability).
Experience with healthcare data standards (FHIR, HL7) andoperatingwithin HIPAA-compliant environments.
Experience mentoring engineers and leading technical initiatives across teams.
Contributions to open-source AI projects, publications, or patents.

OneOncology is a partnership of independent community oncology practices committed to driving the future of cancer care delivery through a patient-centric, physician-driven, and technology-powered model to help improve the lives of everyone living with cancer.
OneOncology empowers community oncology practices by supporting the entire continuum of care, including prevention and diagnosis, research and treatment, and long-term survivorship, palliative, and hospice care. Our technology provides access to key clinical and operational data and the latest research via a cloud-based network. This comprehensive approach supports community oncologists’ transition to value-based care and commitment to providing their patients with access to best-in-class healthcare, close to home.
For OneOncology, cancer is personal, and the mission is critical. Working together with world class oncologists, OneOncology looks to drive the change that community cancer needs through continual learning, creative and smart evolution, and a collective desire to positively impact the lives of every person touched by cancer.
To learn more, visit www.oneoncology.com or follow us on Twitter @OneOncology.