Kodiak Sciences

Senior/Principal Scientist – In Vivo Pharmacology

Kodiak Sciences  •  Palo Alto, CA (Onsite)  •  8 days ago
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Job Description

Kodiak Sciences Inc. is a rapidly growing, clinical-stage biopharmaceutical company dedicated to transforming ophthalmology through innovative therapeutics. Our proprietary Antibody Biopolymer Conjugate Drug (ABCD) platform integrates protein engineering, polymer chemistry, small molecule drug discovery, and advanced drug delivery technologies to address prevalent and debilitating retinal diseases with the goal of improving patient outcomes worldwide.
 
Kodiak Sciences is seeking a highly motivated and independent Senior/Principal Scientist to join the In Vivo Pharmacology team. This role will focus on developing program-specific in vivo pharmacology strategies, establishing pharmacodynamic/efficacy models, and generating preclinical proof-of-concept and pharmacokinetic/pharmacodynamic relationships across portfolio programs. The ideal candidate will possess deep scientific expertise in ophthalmic pharmacology, strong technical and analytical capabilities, and demonstrate leadership in managing complex preclinical studies and external collaborations. This individual will play a critical role in advancing innovative therapeutic candidates in a collaborative, fast-paced research environment.
 
Key Responsibilities
  • Design, execute, and interpret preclinical efficacy, PK/PD, and ex vivo studies to support discovery, lead optimization, and translational research programs.
  • Serve as the in vivo pharmacology subject matter expert on cross-functional project teams and contribute to program strategy and decision-making.
  • Develop and optimize relevant animal models and pharmacology assays to support mechanism-of-action studies and candidate evaluation.
  • Draft, manage, and maintain IACUC protocols in compliance with institutional and regulatory animal welfare requirements.
  • Partner closely with the IACUC committee and support vivarium and laboratory operations to ensure compliance and operational excellence.
  • Provide scientific mentorship, technical guidance, and training to junior scientists and research associates.
  • Manage relationships with CROs and external collaborators to ensure high-quality study execution, timelines, and deliverables.
  • Analyze and interpret complex datasets and communicate effectively through presentations, technical reports, and regulatory documentation.
  • Evaluate emerging technologies and implement innovative approaches to accelerate program timelines and deepen mechanistic understanding.
Education & Qualifications
  • Ph.D. in Pharmacology, Ophthalmology, Neuroscience, or a related discipline with 3+ years of relevant industry experience.
  • Extensive hands-on experience designing, conducting, and interpreting in vivo pharmacology studies, including preparation and management of IACUC protocols.
  • Strong understanding of ophthalmic disease biology, translational pharmacology, animal model development, and standard preclinical pharmacology study designs.
  • Proficiency in animal handling, dosing, blood/tissue collection, and ocular procedures; experience with intravitreal injection is preferred.
  • Experience conducting rabbit studies is highly desirable.
  • Demonstrated ability to independently lead studies and manage multiple priorities in a dynamic research environment.
  • Excellent written and verbal communication skills, with the ability to clearly present complex scientific concepts and data to multidisciplinary audiences.
  • Strong organizational, analytical, and problem-solving skills with attention to scientific rigor and data quality.
 
Kodiak Sciences

About Kodiak Sciences

Kodiak is a biopharmaceutical company committed to researching, developing and commercializing transformative therapeutics to treat high prevalence retinal diseases. We are focused on bringing new science to the design and manufacture of next generation retinal medicines to prevent and treat the leading causes of blindness globally. Our ABC Platform™ uses molecular engineering to merge the fields of antibody-based and chemistry-based therapies and is at the core of Kodiak's discovery engine. Kodiak's lead investigational medicine, tarcocimab, is a novel anti-VEGF antibody biopolymer conjugate under development for the treatment of high prevalence retinal vascular diseases. KSI-501 is our second investigational medicine, a first-in-class anti-IL-6, VEGF-trap bispecific antibody biopolymer conjugate designed to inhibit both IL-6 mediated inflammation and VEGF-mediated angiogenesis and vascular permeability. KSI-501 is being developed for the treatment of high prevalence retinal vascular diseases to address the unmet needs of extended durability and targeting disease biology beyond VEGF for differentiated efficacy. KSI-101, our third product candidate, is a novel anti-IL-6, VEGF-trap bispecific protein for the treatment of retinal inflammatory diseases. We are advancing our platform technology to embed small molecules and other active pharmaceutical ingredients for multifactorial diseases.

WORKING AT KODIAK

We foster a culture of curiosity, creativity, compassion and courage. Our collective goal is to make a difference in the world. We do that as a team driven by the shared desire to tackle some of the world’s biggest challenges. If this sounds exciting, we want to hear from you!

Kodiak supports a vibrant and active lifestyle, striving to provide an optimal work-life balance. We are located in Palo Alto, in the heart of the world-class biotech hub of Silicon Valley, and within walking distance to California Avenue’s shops, restaurants and public transportation.

Industry
Biotech & Life Sciences
Company Size
51-200 employees
Headquarters
Palo Alto, California
Year Founded
2009
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