Senior Scientist – Downstream Analytics (Large Molecules)
Biotech | HPLC | Bioprocessing | Southampton | Up to £50,000 + Benefits
We’re partnering with an innovative scientific organisation to recruit a Senior Scientist with strong experience in downstream analytical processes, including HPLC and bioprocessing techniques, to join a high-performing team based in Southampton. This hands-on role offers the chance to support the development of modified nucleic acids and peptides, drive analytical method development, and contribute to the advancement of large molecule therapeutics in a collaborative, fast-paced environment.
About the Role
You’ll take the lead on analytical workflows for nucleic acids, peptides, and antibodies, ensuring high standards of quality, compliance, and scientific rigour. The role will include method development, instrument maintenance, and cross-functional collaboration across R&D and production teams.
This position is ideal for a scientist who enjoys working across disciplines, mentoring junior colleagues, and staying at the forefront of analytical innovation.
Key Responsibilities
Lead downstream analytical workflows using HPLC, UPLC, PAGE, flash chromatography, and related techniques
Contribute to the purification and characterisation of large molecules, such as peptides and antibodies
Support method development and continuous improvement in analytical approaches
Collaborate with chemistry and production teams to support small molecule and oligonucleotide preparation
Maintain, calibrate, and optimise analytical instrumentation in line with ISO and internal quality systems
Mentor and support Associate Scientists and Lab Technicians
Ensure accurate documentation and maintain data integrity across workflows
Promote and uphold Health, Safety, and Environmental (HSE) standards
Manage stock levels of analytical reagents and consumables
Stay up to date on emerging trends in bioprocessing and analytical technologies
About You
We’re looking for a motivated and collaborative scientist with a solid grounding in downstream analytical techniques and a passion for quality science.
You’ll ideally have:
A PhD (or equivalent experience) in Analytical Chemistry, Biochemistry, or a related field
Strong hands-on experience in HPLC and bioprocessing within a biotechnology, pharmaceutical, or life sciences environment
Knowledge of purification and characterisation methods for peptides, antibodies, or similar large molecules
Experience with TFF or tangential flow filtration (advantageous)
Familiarity with ISO or GMP-regulated environments
Ability to lead technical projects and support team development
Strong communication and problem-solving skills
A flexible, proactive mindset with strong attention to detail
Salary & Benefits
Salary Up to £50,000 depending on experience
Location On-site in Southampton
Holidays 25 days annual leave + 8 bank holidays
Pension 6% employer contribution
Life Assurance 4x salary
Additional Benefits Include:
Flexible working hours
Long service awards and recognition scheme
Employee Assistance Programme with 24/7 remote GP access
Annual flu vaccinations
Cycle to work scheme and gym discounts
Discounts and savings platform
Professional membership reimbursement
Referral incentives
Social events and volunteering days
Cranleigh STEM is a specialist recruitment partner in STEM, Sustainability, and SHEQ. We work with innovative organisations and purpose-led professionals to help solve some of the world’s most pressing challenges, from advancing clean technologies to driving scientific discovery.
We understand that progress in these fields depends on people. Our role is to connect the right individuals with the right teams, whether that’s scientists in the lab, engineers on the ground, or leaders at the helm.
🚀 Our Mission
To support innovative organisations by delivering the talent they need to grow, evolve, and make a meaningful impact in their field.
🔎 Our Core Values
Challenge
We’re comfortable working in complex, technical spaces. We approach every brief with curiosity and care, asking the right questions to deliver people who can genuinely move your organisation forward.
Collaboration
We see recruitment as a partnership. That means open communication, transparency, and shared goals, whether you’re building a team or looking for your next role.
Commitment
We take pride in the work we do. We’re committed to high standards, long-term relationships, and doing what’s right for our clients, our candidates, and the industries we serve.
💡 Our Purpose
To contribute to a more sustainable and innovative future by helping organisations in science and technology attract and retain the talent they need to grow responsibly and with purpose.
🌍 Our Reach
Headquartered in South London, we work with clients and candidates across the UK, Europe, and the USA.
🔬 Areas of Expertise
Biotechnology
Pharmaceuticals
Chemicals & Materials
Food Technology
Clean Technology
Electric Vehicles & Sustainable Engineering
If you're hiring or exploring your next move in STEM, we’re here to help.
