Job Description

Monte Rosa Therapeutics is seeking an energetic and highly motivated Contractor located in Boston to support the development and characterization of novel molecular glue degraders for the treatment of inflammatory diseases. As part of the Immunology and Preclinical Pharmacology team, this role will broadly support multiple immunology and inflammation (I&I) projects/programs from early lead optimization through clinical-stage.

The ideal candidate is an experienced experimentalist with a strong background in I&I and a demonstrated ability to work collaboratively to achieve team/company goals.

Responsibilities

• Design, optimize and execute experiments using a variety of primary immune cells and tissues isolated from human, mouse or cynomolgus monkey (including PBMCs, monocyte-derived macrophages, whole blood, synovial fluid, peritoneal fluid, etc.)
• Routine profiling of compounds using Meso Scale Discovery (MSD), ELISA, Western blot, Simple Western (Jess), flow cytometry, qPCR assays
• Ex vivo mouse tissue processing (spleen, bone marrow, lymph node, etc.)
• Maintain timely and detailed notes using electronic lab notebook

Qualifications

• MS or PhD equivalent in Immunology or Cell Biology with 3+ years of hands-on experience in I&I drug discovery research in a pharmaceutical setting
• Extensive experience handling whole blood, primary immune cells and tissue (preferably including clinical samples)
• Expert in protein detection/quantitation methodology (e.g., MSD, ELISA, Western blotting, Jess)
• Flow cytometry expertise is preferred
• Highly proficient with Microsoft Excel, GraphPad Prism (FlowJo is preferred)