Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays
Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)
Support development and validation of new ADME assays to expand the group’s scientific capabilities
Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)
Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators
Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable
Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions
Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams
Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics
Master's in Lifescience with 4-5 years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.
Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles
Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments
Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding
Ability to troubleshoot experimental challenges and apply sound scientific judgment
Self-driven and capable of managing multiple tasks while working within demanding project timelines
Strong attention to detail and commitment to maintaining high scientific and data quality standards
Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams
Strong communication skills for interacting with internal teams, collaborators, and stakeholders
Highly organised with the ability to function effectively in a fast-paced research environment
Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs
A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h
o2h group seeds new ideas in science, technology and green innovation. We work across boundaries and take a collaborative and shared approach to innovation, and therefore we co-invest, co-create and co-execute to bring these ideas to life. o2h group is organised into 6 symbiotic verticals; o2h ventures, o2h discovery, o2h therapeutics, o2h technology, o2h co-work, and o2h community.
o2h discovery is an integrated chemistry and biology services platform for executing collaborative research. o2h technology works on proprietary software projects for in-house portfolio companies.
o2h ventures is an engine for nurturing early stage life science and technology assets through seed investment.
o2h therapeutics is seeding a novel pipeline of proprietary pre-clinical IP in Immunoncology (glioblastoma, breast cancer), anti-ageing and diabetes.
o2h co-working space located in Hauxton, Cambridge, UK and o2h community covers our work with local non-profits organisations, our interests in working with social enterprise and our work in creating a community of innovators that can impact society.
o2h group is co-located in Ahmedabad, India and in Cambridge UK. Please see www.o2h.com for more details.
