Job Description

We are Pierre Fabre Laboratories, a global leader combining pharmaceutical expertise with dermo-cosmetics to support consumers and patients at every stage of their care journey.
Our portfolio includes several medical franchises and international brands such as Eau Thermale Avène, Ducray, A-Derma, Klorane, René Furterer, and Pierre Fabre Oral Care.
By joining us, you become part of a meaningful company where the human dimension is essential. You become a participant in the "We Care Movement," a movement that values excellence and innovation within passionate teams. Together, we push the boundaries of science to unite health and beauty for the benefit of all, because Every time we care for a single person, we make the whole world better.

Present in 120 countries with a team of over 10,000 employees, we are proud to create a scientific and human impact, today and tomorrow! If caring is at the heart of your values, join Pierre Fabre Laboratories and become a key player in the “We Care Movement".

Your mission

We are seeking for the R&D Pharma in Toulouse a skilled Pharmacokinetics / Pharmacodynamics (PK/PD) Scientist to support our Dermatology, Oncology & Rare Diseases Drug Discovery portfolio.

The ideal candidate will prove expertise in PK/PD, with an understanding of dermatological biology, skin‑targeted drug delivery, and translational sciences. This role is critical in guiding decision‑making from early discovery through candidate selection.

The PK/PD Scientist will partner closely with discovery biology, medicinal chemistry, DMPK, toxicology, and clinical development teams to optimize compound selection, design robust translational strategies.

The incumbent will collaborate in AI& data‑driven development of innovative therapies, understanding of how AI‑derived properties relate to downstream outcomes (PK, efficacy, safety, human dose).

Your role within a pioneering company in full expansion:

Cross‑Functional Collaboration & Leadership

• Serve as the PK/PD and/or PBPK representative on multidisciplinary project teams.
• Provide strategic input for compounds selection/prioritization, study design, assay prioritization, biomarker selection, and overall program strategy.
• Communicate modeling assumptions, results, and recommendations to scientific teams and senior decision‑makers.

PK/PD Modeling & Quantitative Sciences

• Characterize exposure–response relationships for efficacy, biomarkers, target engagement, and safety.
• Support dose and schedule optimization across modalities (small molecules, biologics, ADCs, topical/intradermal agents).
• Integrate PK, PD, biomarker, and efficacy data to enable translational predictions and improve candidate selection.
• Support predictions of human PK, human effective dose and local vs systemic exposure.
• Use and refine PBPK models to project tissue distribution, including:
  • tumor penetration (oncology)
  • skin and dermal distribution (dermatology)
  • Contribute PBPK analyses to IND enabling packages and early clinical strategy.

Oncology Drug Discovery Support

• Implement quantitative frameworks for tumor growth inhibition (TGI) models and immune‑oncology mechanisms.
• Support MoA exploration, combination‑strategy modeling, and therapeutic index assessment.
• Translate preclinical PK/PD and/or PBPK findings into first‑in‑human guidance.

Dermatology Drug Discovery Support

• Apply PK/PD and/or PBPK approaches to understand cutaneous absorption, skin barrier penetration, and dermal pharmacokinetics.
• Support optimization of topical formulations, systemic agents with skin‑selective activity, and disease‑relevant biomarker strategies.
• Integrate skin PK according to patient population, lesion‑level response, and biomarker data to guide lead optimization.

Software, Data Handling & Documentation

• Use industry‑standard tools (e.g., Phoenix NLME) to perform high‑quality modeling and simulation.
• Ensure rigorous documentation and reproducibility of modeling workflows, results, and insights.
• Author internal documents (as needed).

This position is compatible with teleworking up to 2 days a week according to company rules.

We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation...

Your skills at the service of innovative projects:

Previous experience (+5 years) in integrated solution combining PK/PD and/or PBPK expertise with direct oncology and dermatology support, including mechanistic understanding and translational alignment for oncology/dermatology-focused drug discovery programs.

In particular:

• Integration of PK/PD and or PBPK modeling and biomarker strategies essential for translational validity.
• Ability to support both early discovery (PoM/PoP) and (pre)clinical translation ensuring continuity across the development pipeline.
• Experience in Oncology, including TGI modeling, immune‑oncology PK/PD, or modeling for SM biologics/ADCs.
• Focus on discovery & preclinical models relevant to dermatology, including topical delivery, local tissue PK, and skin barrier modeling (e.g., human skin explants, iPSC-derived keratinocytes, in vivo inflammation models…).
• Collaboration with experts familiar with AI/in silico ADMET, interpreting AI outputs in biological context , oncology/dermatology-specific pharmacology, inflammation, and PD biomarkers enhancing predictive power.
• bespoke PK/PD and/or PBPK modeling, linking complex preclinical experiments to (pre)clinical strategy.

At Pierre Fabre Laboratories, we believe that our greatest asset is our people.

We are committed to a policy of Equal Employment Opportunity and will not discriminate against an applicant or employee based on race, color, religion, creed, national origin or ancestry, sex, sexual orientation, gender identity or expression, age, physical or mental disability, veteran or military status, genetic information, or any other legally recognized protected basis under federal, state, or local law. The information collected by this application is solely to determine suitability for employment, verify identify, and maintain employment statistics on applicants. Applicants with disabilities may be entitled to reasonable accommodation under the Americans with Disabilities Act and certain state or local laws. Please inform the company’s personnel representative if you need assistance completing this application or to otherwise participate in the application process. Thus, we commit to considering all applications equally, without fail.