Job Description

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Immunome is seeking an onsite Senior IT Systems and Support Technician to serve as an experienced technical lead and key contributor to enterprise systems administration, infrastructure operations, IT service management, and cybersecurity within a regulated biotech environment.

This role blends advanced Tier 3 support with hands-on systems administration across Microsoft 365, identity and endpoint management, enterprise applications, and laboratory systems. The ideal candidate has strong experience in ITIL-based environments and hands-on expertise with ServiceNow IT Service Management (ITSM).

This person will help ensure the reliability, security, scalability, and regulatory compliance of corporate and GxP-regulated IT systems supporting teams across the organization.

Responsibilities

Advanced Technical Support

• Serve as Tier 3 escalation for complex technical issues across endpoints, infrastructure, applications, and cloud environments.
• Mentor and provide guidance to Tier 1 and Tier 2 support technicians.
• Serve as a senior power user and operational subject matter expert for ServiceNow.
• Ensure complete and high-quality documentation of incidents, changes, and resolutions within ServiceNow.
• Support continuous improvement of ITSM processes aligned with ITIL best practices.
• Develop SOPs, knowledge base articles, and technical documentation.
• Coordinate support activities with IT Managed Service Providers (MSPs), vendors, and internal partners.
• Participate in on-call rotation and after-hours support as required.

Systems Administration and Enterprise Application Support

• Administer Microsoft 365 (Exchange Online, Teams, SharePoint, Cloud PC, Entra ID).
• Serve as system administrator for business-critical enterprise applications (ERP, CRM, HRIS, EDMS).
• Provide IT support for research and development laboratory systems
• Oversee endpoint management platforms (Intune, JAMF, NinjaOne).
• Manage Windows and macOS workstations, mobile devices (iOS and Android), and client software applications.
• Follow formal change management processes for regulated systems.
• Contribute to infrastructure planning and lifecycle management initiatives.

Cybersecurity and Compliance Support

• Serve as secondary administrator for selected cybersecurity systems.
• Assist with security incident response and risk remediation efforts in collaboration with internal leadership and external SOC/MSP partners.
• Support Endpoint Detection and Response (EDR), patch management, and device compliance programs.
• Help manage identity and access controls (MFA, SSO, RBAC, conditional access).
• Maintain GxP-regulated systems in compliance with FDA 21 CFR Part 11 and data integrity requirements.
• Partner with Finance, Legal, and Quality during regulatory audits and inspections.

Qualifications

• A minimum of 5+ years of progressive IT support and systems administration experience.
• A minimum of 2+ years in a Tier 3 or senior technical role.

Preferred Certifications

• Microsoft (M365, Azure, Intune, Windows Server)
• ITILv4 Foundation
• ServiceNow Certified System Administrator (CSA)
• CompTIA A+, Network+, Security+
• Security-related certifications (CySA+, CISSP, or equivalent) a plus

Knowledge and Skills

• Strong hands-on experience with ServiceNow ITSM.
• Experience supporting on-premise and cloud computing environments.
• Strong troubleshooting, documentation, and communication skills.
• Experience in regulated industries (biotech, pharma, medical device) preferred.

Washington State Pay Range $102,777—$131,784 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish)