
The Senior Director, Portfolio & Program Management is a global role within the Program and Portfolio Management (PPM) organization. The incumbent is responsible for championing cross-functional project management excellence to programs across the drug development lifecycle (Research, Pre-clinical and Clinical Development, Registration and Commercialization). The incumbent is expected to lead the application of project management to identify opportunities, shape objectives and drive execution of global strategy for cross-functional drug development teams and portfolio operations initiatives. This role is a key leadership position within PPM, with accountability for the performance and end results of a department/area.
Provide strategic and operational project leadership to one or more cross-functional teams, directing activities at all stages of the project lifecycle (initiation through closeout)
Drive communication cross-functionally and with senior leaders on integrated program planning topics including timelines, status, risks and issues
Proactively identify roadblocks and/or constraints impacting strategic imperatives or project execution and lead the team through scenario planning activities
Partner with governance forums, senior leaders and/or team lead(s) to align strategy, goals and milestones with corporate objectives
Propose innovative approaches, define process improvements and advise leaders on opportunities to optimize project results
Determine approach and stakeholders for cross-functional decision-making and issue resolution
Oversee completion of project team deliverables and contribute to content development, when appropriate
Establish project team operating norms and measure performance
Apply subject matter expertise to mentor subordinate managers and high level professionals
As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned high level professionals and subordinate managers
Broad and comprehensive understanding of project and portfolio management principles, options analysis, strategic planning, business case generation, finance and resource management
Leadership experience managing cross-functional teams with an ability to influence teams to prioritize activities and allocate resources to contribute to the development of operational strategy
Excellent written and oral communication skills, including well-developed presentation skills
Pharmaceutical drug discovery and development expertise across multiple disciplines
Organizational skills, an ability to manage multiple priorities
Strong collaboration skills to effectively interact with internal or external stakeholders at all levels in the organization
Advanced business management knowledge to assess the impact of project decisions on financial and corporate objectives
Typically requires a Bachelor’s degree in Life Sciences or a relevant field
Typically requires 12 years of experience and 5 years of management experience, or the equivalent combination of education and experience
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
$242,200 - $363,200
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Hybrid-Eligible Or On-Site Eligible
In this Hybrid-Eligible role, you can choose to be designated as:
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and have made significant advancements in multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continue to progress clinical and research programs in these diseases. We also have a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where we have deep insight into causal human biology, including acute and neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy, autosomal dominant polycystic kidney disease, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency.
Our global HQ is in Boston, and we have research and development (R&D) sites and commercial offices worldwide.
Vertex is consistently recognized as one of the industry’s top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. We have also earned a spot on TIME Most Influential Companies, TIME Best Inventions, and Fast Company Most Innovative Companies lists. Our research and medicines have received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the Prix Galien, the Scrip Award and the Breakthrough Prize awards.
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