Job Description

Immunome is seeking a Senior Director, U.S. Market Development to lead and provide strategic direction for commercial market development activities in preparation for the potential launch of varegacestat in desmoid tumors. This role will be responsible for shaping the U.S. commercial and clinical landscape ahead of launch by building strategic relationships with key opinion leaders (KOLs), generating actionable market insights, and translating those insights into launch strategy. The Senior Director will ensure the U.S. market is informed, aligned, and ready for varegacestat at approval.

As a senior member of the U.S. Commercial organization, this individual will partner cross-functionally with Sales, Marketing, Market Access, Medical Affairs, Clinical Development, and HEOR to ensure launch plans are grounded in real-world insights and reflect the evolving treatment paradigm in desmoid tumors. The mission of this role is to help position varegacestat for strong adoption by establishing Immunome as a trusted commercial and scientific partner within the U.S. desmoid tumor community.

Responsibilities

U.S. Market Development & Launch Readiness

• Lead the development and execution of the U.S. market development strategy for varegacestat, aligned with commercial launch objectives.

• Define, prioritize, and implement pre-launch initiatives that prepare the market for approval and early adoption.

• Identify and proactively address barriers to uptake, including referral patterns, treatment sequencing dynamics, and care setting variability.

• Provide senior-level strategic input into:

• • U.S. positioning and messaging.

• • Target product profile refinement.

• • Disease awareness initiatives.

• • Field force strategy and engagement model.

• Partner closely with Marketing and Sales leadership to drive alignment and ensure launch readiness milestones are met.

U.S. KOL Strategy & Commercial Engagement

• Lead the mapping, segmentation, and prioritization of U.S. KOLs and high-impact treatment centers across academic and community settings.

• Build and sustain credible, compliant relationships with leading desmoid tumor experts, sarcoma specialists, and multidisciplinary stakeholders.

• Lead commercial KOL engagement through:

• • 1:1 strategic discussions

• • U.S. advisory boards.

• • Regional roundtables.

• • National congress engagement (ASCO, CTOS, SSO, etc.).

• Ensure insights from engagements are systematically captured and translated into actionable strategic commercial recommendations.

Insight Generation & Competitive Intelligence

• Direct ongoing assessment of the evolving U.S. treatment landscape, including standards of care, off-label usage patterns, and competitive dynamics.

• Oversee the generation of structured insight reports that inform:

• • Brand strategy.

• • Forecasting assumptions.

• • Access strategy.

• • Lifecycle planning.

• Monitor competitive activity and emerging data that may impact launch strategy.

Congress Strategy & External Presence

• Provide senior commercial leadership for U.S. congress planning and execution, including:

• • KOL engagement planning.

• • Competitive intelligence capture.

• • Post-congress insight synthesis.

• Lead or contribute to the development of U.S. advisory boards and strategic planning meetings in support of launch.

Cross-Functional Collaboration

• Partner closely with:

• • Marketing on brand strategy and disease education.

• • Sales Leadership on field readiness and targeting.

• • Market Access on value narrative and payer insights.

• • Medical Affairs to ensure alignment and compliance of scientific exchange.

• Serve as a senior commercial bridge between external market insights and internal launch decision-making.

Qualifications

• Bachelor's degree required.

• A minimum of 14 years of experience in oncology biopharma or equivalent, with significant exposure to U.S. commercial strategy, market development, or launch planning and progressively increasing leadership responsibility.

• Extensive experience building and leading a team for an oncology launch.

• Minimum of 5 years of experience leading highly successful sales teams.

• Prior experience leading U.S. oncology product launches is required.

• Willingness to travel within the U.S. (approximately 40-50%).

Knowledge and Skills

• Experience in rare oncology, sarcoma, or specialty markets highly desirable.

• Strong understanding of U.S. treatment dynamics, referral networks, and access landscape.

• Proven ability to translate field insights into strategic commercial actions and influence senior-level decision-making.