About Plume:
Plume is a passion-fueled, mission-driven company that is trans-founded with a vision to transform healthcare for every trans life. We hope to make gender-affirming hormone therapy easily accessible at the touch of a button in every state of the US.
This work is deeply personal and heart-driven, and we want teammates who care about the mission and the people we serve. For the right candidates, we present a rare opportunity to do well by doing good. Plume offers an affirming, trans-centered, culturally inclusive, and fun work environment filled with purpose.
The Senior Data and AI Engineer is a high-impact individual contributor on the Data and AI team. This role will be tasked with building, maintaining, and optimizing the data pipelines, transformation models, and BI deliverables. Applied AI (RAG pipelines, MLOps) is a growing area of the role, not the primary focus today.
The right person for the role will be a skilled, self-sufficient engineer who takes well-defined architectural direction and executes it with precision, quality, and ownership. They will also contribute their own technical judgment to day-to-day implementation decisions.
They are deeply hands-on: writing production dbt models, building Airflow DAGs, delivering clinical dashboards, and contributing to RAG pipelines and MLOps workflows within a regulated healthcare environment. You will also work closely with offshore contractors, reviewing their work, providing feedback, and ensuring output meets the team's quality and engineering standards.
The ideal candidate will have a strong command of cloud data warehousing, dimensional modeling, Python, and applied AI tooling, as well as a collaborative mindset that thrives in a team-oriented environment. This role is an excellent opportunity for a senior engineer looking to deepen their full-stack data and AI expertise alongside experienced technical leadership.
All Full-Time Employees are Eligible for:
• Ground-Floor Equity (Series B)• Free Medical, Dental, and Vision on the first of the month after you start full-time work• Unlimited PTO• 11 paid holidays and company shut-down for a week in December• 401(k)• Free Plume and BetterHelp Subscriptions
Everyone associated with Plume gets the major benefit of having the best coworkers you could imagine if you love fiercely intelligent, heart-forward, and mission-driven collaborators.
At Plume, we structure our compensation to reflect cost-of-living differences across regions. Our salary tiers are based on the cost of living relative to the national average. We use these tiers to maintain fair and competitive compensation across all locations. Tier placement will be discussed during the offer stage.
Plume is an equal-opportunity employer. Trans and gender-nonconforming individuals are strongly encouraged to apply, particularly those who identify as People of Color. We positively encourage applications from suitably qualified and eligible candidates regardless of age, color, disability, national origin, ancestry, race, religion, gender, sexual orientation, gender identity and/or expression, veteran status, genetic information, or any other status protected by applicable law. We will provide reasonable accommodations to individuals with disabilities upon request. Please let us know if you require any accommodations to apply or interview for this position.
Only those legally authorized to work in the USA are eligible to apply; residency in the USA is a requirement of employment for this role.
Discover more about Plume at www.getplume.co and become part of our award-winning journey towards transforming healthcare for every trans life. Join us today in shaping the future of healthtech and LGBTQ+ care!
Please be aware that employment scams are on the rise. Plume will only contact candidates using an official "@getplume.co" email address. Plume does not conduct interviews via email and will never request banking information through text or email. Please protect your information!
We’re so grateful for your interest in joining our team! To help us keep our operations running smoothly and ensure fair consideration for all candidates, we kindly ask that you refrain from reaching out to staff members directly regarding open roles.

Plume Clinic provides accessible, gender-affirming care designed by and for trans and gender-diverse adults. Our trans-led team offers trusted medical care, peer support groups, and educational events—all accessible from your phone. Whether you’re starting your transition or have been on your journey for years, we’re here to support trans people every step of the way. Join us in transforming healthcare for every trans life.