Job Description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.

• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

We are seeking a Senior Clinical Research Associate (CRA) to support our Clinical Operations team. The Senior CRA will be responsible for overseeing clinical trial site management and monitoring activities to ensure compliance with ICH-GCP, regulatory requirements, and company SOPs. In this role, you will partner closely with clinical sites and cross-functional teams to support high-quality study execution, patient recruitment, and operational excellence across clinical trials.

Reports to Associate Director, Team Lead Site Operations

Location Fully Remote

Salary Range: $120,000 to $135,000

Basic Qualifications:

• Bachelor’s degree in life sciences, nursing, or a related field

• 4+ years of on-site monitoring experience within the pharmaceutical or biotechnology industry, including all clinical monitoring visit types

• Strong knowledge of ICH-GCP, FDA, EMA, and applicable clinical trial regulations

• Demonstrated experience managing clinical trial sites, monitoring activities, and clinical trial documentation

• Proficiency with clinical trial systems and tools (e.g., CTMS, eTMF, Microsoft Office)

Preferred Qualifications:

• Experience in oncology clinical trials or related therapeutic areas

• Advanced presentation, organizational, and stakeholder management skills

• Experience mentoring or training junior CRAs and supporting cross-functional clinical operations activities

• Demonstrated ability to drive quality, efficiency, and continuous improvement initiatives in clinical operations

• Strong understanding of clinical trial recruitment strategies, data capture, and site engagement best practices

• Experience contributing to global harmonization, process optimization, or operational innovation initiatives

In this role you will:

• Conduct all clinical monitoring activities, including site qualification, initiation, routine monitoring, and close-out visits

• Support site feasibility, site selection, and ongoing site management activities throughout the clinical trial lifecycle

• Review clinical trial progress, patient recruitment, and data quality metrics, and implement actions to support study objectives

• Maintain accurate and timely monitoring documentation, including trip reports and trial master file records

• Collaborate with vendors, clinical sites, and cross-functional teams to support study execution and operational compliance

• Participate in investigator meetings, clinical trial documentation development, and study team meetings

• Mentor junior CRA team members and contribute to continuous improvement of clinical operations processes and procedures

Travel required: Willingness to travel up to 75%. Valid Driver's License preferable.

Qualified candidates will participate in a structured interview process, which includes:

• An initial recruiter phone screen (conducted via video)

• A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video)

• A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX

What do we offer? 

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics

Comprehensive Benefits 

• Competitive rates for Health, Dental, and Vision Insurance

• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.

• 12 company paid holidays

• 7 days of sick time

• 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars

• 100% employer-paid short- and long-Term disability coverage 

• 401(k) with immediate eligibility and company match…

  • The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.

• Partially paid parental leave for eligible employees.

• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity 

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace.  We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.   

Reasonable Accommodations 

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances.  If you require assistance or accommodation during the application or interview process, please contact us at RecruitingUS@immatics.com   

Work Authorization 

Applicants must be authorized to work in the United States without the need for current or future sponsorship.  Visa sponsorships may be available for certain roles. 

Pre-Employment Requirements 

Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law.  For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.