T he ideal candidate will havestrongbackground in pharmacokinetics and translational modeling. You willparticipatein implementing innovative and quantitative approaches to advance clinical drug development.Developing, qualifying, and applying mechanistic PBPK modelsusing invitro, preclinical, clinical, and literature data to support clinical development decisions across therapyareasIn addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP)asperyour experience, interests,andexpertisedictate
Typical Accountabilities
Utilizephysiologically-basedpharmacokinetic (PBPK)and translational modeling tools to enable clinical PK projections fordrug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questions
Collaborate withDrug Metabolism and Pharmacokinetic (DMPK) Scientistsand Clinical Pharmacology scientists to generate these mechanistic models
Develop fit-for-purpose, qualified PBPK models suitable for internal decision-making and regulatory use, including support forsubmissiondocumentation and health authorityinteractionsCommunicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions
Keep up to date with emerging literature, modeling science, and regulatory expectations
Education, Qualifications,Skillsand Experience
Essential
PhD degree preferred or equivalent (M.Sc./Pharm.D.)
Experience using PBPK platforms such asSimcyp,GastroPlus, or PK-Sim, together with scripting in R and/or Python for data analysis, visualization, and workflow automation.
Familiarity with AI-enabled scientific workflows, such as literature mining, codingassistance, or document summarization in compliant research environments
Demonstrated broadPBPKexpertiseand experience exemplified by 1-4 Years of drug development experience, with emphasis onPBPK modelling
Good knowledge inpharmacokinetics, drug-drug interactions, regulatory guidance in clinical pharmacology,modellingand simulation sciences
Demonstrated ability toidentify,developand executePBPKactivities at a project level
Good oral and written communication skills
Good knowledge of global regulatory, compliance, processes,standardsand issues specific toPBPK
with relevant experiencerequired
Experience authoring or contributing to PBPK technical reports and regulatory documentation, including submission-ready analyses and responses to health authority queriesFluency in spoken and written English language
Desirable
Areputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology
Experience in early andlate-stagedrug development
Date Posted
03-jul-2026
Closing Date
16-jul-2026
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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