
A-Alpha Bio is an early-stage, rapidlygrowing biotechnology platform companyheadquartered in Seattle, WA.We are focused on building the foundational data layer for AI-driven protein engineering.Weprovide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models.In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics
Candidates must reside in the United States.
Starting Salary Range: $245,000 - $275,000 OTE (Base Salary: $120,000 - $150,000 + Target Incentive: $125,000)
Exemption Status: Exempt
Location Expectations Remote-Eligible
Reporting To Director, Commercial Sales & Operations
A-Alpha Bio is seeking a Senior Account Executive to own the end-to-end sales process for our Western North America and APAC territoriesTypically, these deals are complex, consultative, and large-dollar-value technical sales made to scientific buyers at pharmaceutical companies, biotechnology companies, AI model-makers, and similar organizations. Success in this role will require hunting new logos, expanding existing accounts, and carrying a bookings quota across the full product portfolio. Cross-functional work with marketing, technical, and other internal teams is a key part of this role.
Key Responsibilities
Qualifications & Experience
Required
Preferred
In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.
A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!

A-Alpha Bio is a biotechnology company harnessing synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions. Our experimental platform, AlphaSeq, enables the rapid and quantitative measurement of millions of protein-protein binding affinities simultaneously. Our computational platform, AlphaBind, is trained on the world’s largest protein-protein interaction database and predicts binding strength from sequence. A-Alpha Bio leverages AlphaSeq and AlphaBind for in-house therapeutic programs and in partnership with leading pharmaceutical companies to inform the discovery and development of novel therapeutics. A-Alpha Bio is based in Seattle and was founded in 2017 at the University of Washington's Institute for Protein Design and Center for Synthetic Biology. To learn more, please visit: https://www.aalphabio.com/