Job Description

• Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays
• Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)
• Support development and validation of new ADME assays to expand the group’s scientific capabilities
• Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)
• Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators
• Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable
• Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions
• Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams
• Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics

Requirements

• Master's in Lifescience with 7+ years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.
• Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles
• Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments
• Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding
• Ability to troubleshoot experimental challenges and apply sound scientific judgment
• Self-driven and capable of managing multiple tasks while working within demanding project timelines
• Strong attention to detail and commitment to maintaining high scientific and data quality standards
• Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams
• Strong communication skills for interacting with internal teams, collaborators, and stakeholders
• Highly organised with the ability to function effectively in a fast-paced research environment
• Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs
• A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h