Job Description

SHIFT:

Day (United States of America)

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.

CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.

A Brief Overview
This role participates in a planned research project by performing research protocols. Works independently and self-directed as assigned, providing oversight and technical training to other research staff. Needs a specialized education in the biological or chemical sciences and is required to consistently exercise discretion and judgment in execution, interpretation of experiments, and of data derived.

George laboratory studies the molecular basis of coagulation and aims to develop gene therapies, including gene editing, for disorders of hemostasis and thrombosis. Current work is specifically focused on biochemical function of coagulation factor VIII and the development of personalized gene editing for congenital bleeding and clotting disorders. More information can be found at:

https://www.med.upenn.edu/apps/faculty/index.php/g275/p8583735

https://www.chop.edu/news/childrens-hospital-philadelphia-secures-five-year-389-million-arpa-h-award-advance

https://www.research.chop.edu/clinical-in-vivo-gene-therapy

A Research Technician IV is a vital member of the George laboratory staff and will work collaboratively with other members in the lab, while thinking and working independently. A strong preference is given for anyone with a background in biochemistry, molecular biology and/or genetics. There is a preference for individuals interested in going on to pursue graduate school.

What you will do

• Independently performs advanced, complex research procedures on experimental samples
• Formulates and performs complex lab experiments and analyzes/ reports the data, including interpretation of methodologies
• Independently performs tasks that require knowledge of advanced techniques and lab equipment
• Performs advanced calculations and maintains appropriate log and lab notebooks
• Plans and modifies research protocols and procedures with minimal direction from the principal investigator, supervisor or other designee
• Assists in development & troubleshooting of new techniques and ideas
• Prepares laboratory reagents, monitors and maintains laboratory inventory
• Supervises, trains and mentors junior and new staff members
• Determines staff work assignments, schedules and laboratory priorities as directed
• Presents & discusses work at weekly lab meetings and national symposia
• Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
• Assists in writing of grants, journal articles, posters and oral presentations

Education Qualifications

• Bachelor's Degree - Required

Experience Qualifications

• At least three (3) years of classroom and directly relevant and progressive (increasingly complex/ advanced) lab experience - Required
• Previous lead or supervisory experience in a research lab environment - Preferred

Skills and Abilities

• Advanced understanding of lab procedures, protocols, and equipment. (Required proficiency)
• Advanced proficiency in various research and/or analytical techniques. (Required proficiency)
• Basic proficiency in experiment design and troubleshooting (Required proficiency)
• Excellent verbal and written communications skills (Required proficiency)
• Excellent organizational skills (Required proficiency)
• Excellent critical thinking / problem-solving skills (Required proficiency)
• Excellent analytical skills (Required proficiency)

Preferred Skills

• Cloning, PCR, ddPCR
• Use of laboratory equipment including HPLC, FPLC, spectrophotometer and fluorimeter, ion- exchange for protein purification
• Cell culture, maintaining and creating new stable cell lines
• Learn and use biochemical techniques including performing enzyme kinetic assays
• Use molecular methods including SDS-PAGE, ELISA and western blotting
• Actively engage in learning new techniques and contribute to process improvement
• Communicate clearly with colleagues, contribute to lab meetings and work collaboratively
• Ability to work with murine models
• Ability to prioritize work, exercise discretion, multi-task and actively contribute to laboratory activities

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.

EEO / VEVRAA Federal Contractor | Tobacco Statement

SALARY RANGE:

$53,000.00 - $66,300.00 Annually

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

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At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.