Primary Work Address: Leichtag Biomedical Research Building, La Jolla, CA, 92093-0646
The Sternson Lab at the University of California, San Diego investigates how neural circuits control appetite and motivated behavior. A major focus of the laboratory is the development of CaRMA imaging, an experimental framework that links large-scale measurements of neural activity in behaving animals to post hoc molecular identification of the same recorded neurons. We use advanced in vivo two-photon calcium imaging together with spatial transcriptomic and circuit-mapping approaches to determine how molecularly defined neural populations control food seeking, consumption, and satiety. More information can be found at https://sternsonlab.com/.
The Sternson Lab is seeking a Research Specialist with substantial expertise in in vivo two-photon imaging of the mouse brain. This person will serve as the lab’s primary technical and scientific resource for in vivo two-photon imaging and will take primary responsibility for the imaging component of CaRMA imaging.
The position combines four closely linked responsibilities: performing in vivo calcium-imaging experiments, developing and optimizing methods for imaging neural activity in behaving mice, taking substantial ownership of imaging-data analysis, and enabling other researchers in the lab to successfully apply two-photon imaging in their experiments.
The Research Specialist will work across the full imaging workflow, from surgical preparation and data acquisition through image processing, quantitative analysis, and alignment of functional imaging data with post hoc molecular information. A major part of the role is method development: identifying technical limitations, troubleshooting experiments, improving imaging quality and stability, and establishing robust approaches that can be used across projects.
This is a highly collaborative position. The Research Specialist will work closely with lab members to design imaging experiments, train researchers in imaging and analysis methods, and provide ongoing technical support as two-photon imaging is incorporated into diverse studies of neural circuit function.
We are looking for an experienced, technically creative scientist who enjoys solving experimental problems, developing new methods, analyzing complex datasets, and helping others use advanced imaging approaches effectively.
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
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Hiring Pay Range
$75,200.00 - $94,000.00
Pay Type:
Annual
The posted range reflects HHMI’s good faith estimate of the anticipated hiring salary range for this role at the time of posting. Actual hiring compensation is determined by a candidate’s qualifications, experience, and internal equity.
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Founded in 1953, HHMI invests in scientists at all career stages who make discoveries that advance human health and our fundamental understanding of biology. The institution also supports innovative approaches to science education and public engagement to energize the next generation of scientists, and to foster public appreciation for science. HHMI advances pathbreaking science at more than 60 host institutions across the US and at our Janelia Research Campus in Ashburn, Virginia, where — since its founding in 2006 — Janelia researchers have made discoveries and developed cutting-edge tools that have reimagined what's possible in science.
