Job Description

SHIFT:

Day (United States of America)

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.

CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.

A Brief Overview
Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

The Warren laboratory at the Children’s Hospital of Philadelphia is seeking a highly motivated, collaborative, and creative post-doc to join our growing team. We study normal and malignant hematopoiesis. Our work is informed by the study of germline disorders that cause global failure of hematopoiesis (bone marrow failure syndromes) or those that specifically impact neutrophil formation (severe congenital neutropenia). We have a particular interest in genes that impact mitochondrial function, and how this translates into impaired stem and progenitor cell function. Our long-term goal is to use the knowledge gained from studying the biology of hematopoiesis and granulopoiesis to develop new therapies and surveillance strategies. This could impact patients with rare inherited bone marrow failure disorders, but also patients undergoing treatments such as hematopoietic stem cell transplantation, chemotherapy, or gene therapy.

Current projects in the lab investigate:

• Understanding the role of a mitochondrial protein folding chaperone (CLPB) in normal granulopoiesis
• Investigating the hematopoietic stem and progenitor cell phenotype of CLPB-deficient mice
• Studying the role of RUNX1 somatic mutations in pre-leukemic evolution within congenital neutropenia syndromes
• CRISPR/Cas9 screen and high-throughput drug screen to identify essential determinants of granulopoiesis to develop a cell therapy

Joining the Warren laboratory would provide the following:

• Access to state-of-the-art facilities at the CHOP, Penn, and Wistar institutes
• Collaborative research environment working with world leaders in basic and translational hematopoiesis / leukemia biology
• Opportunities to participate in multiple work-in-progress style meetings with field leaders, and to attend seminars across the CHOP and Penn campuses
• Strong, available mentorship with a focus on the post-doctoral scholar’s long-term career development

Strong candidates will possess the following traits and skills:

• Good communication, strong interest in collaboration
• Strong organizational skills, attention to detail, experience with learners
• Laboratory skills including:
  • Animal handling, colony management
  • Multi-color flow cytometry (prefer experience with at least 7-8 color flow)
  • Fluorescence assisted cell sorting (FACS)
  • Sterile tissue culture of both adherent and suspension cells
  • Production of lenti- or retro-virus

Interested candidates should prepare the following:

• A cover letter describing research experiences and career goals
• Curriculum vitae
• Contact information for three references

What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate Required

Skills and Abilities

• Ability to wear a respirator device

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.

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SALARY RANGE:

$20,800.00 - $110,400.00 Annually

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

If you are applying for a Research Post-Doctoral Fellow role, please refer to this link for salary guidelines (copy & paste into your browser): https://www.research.chop.edu/services/hiring-a-postdoctoral-fellow#collapse-accordion-3523-3

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At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.