The Wyles lab in the Mayo Clinic Department of Dermatology is seeking a highly motivated postdoctoral fellow to study the association between cutting-edge biomarkers of skin health span and tissue engineering In this role, the candidate will lead independent projects focused on defining the molecular and cellular mechanisms of skin senescence using advanced human skin models, with relevance to aging, regeneration, and longevity biology. The successful candidate will bring strong PhD-level training in molecular and cellular biology and will work at the interface of wet-lab experimentation and multi-omic data interpretation in a highly collaborative, interdisciplinary environment. The ideal candidate will be skilled in and have experience in:
• Molecular and cellular biology techniques, including PCR/qPCR and molecular assays
• Primary and immortalized skin cell culture, including keratinocytes, melanocytes, and fibroblasts
• Histopathology, immunohistochemistry, immunofluorescence, and advanced staining techniques
• Quantitative image analysis and data interpretation
• Molecular and cellular analyses related to aging, senescence, and tissue regeneration
• 3D skin equivalents, explants, organotypic cultures, or other in vitro human skin models
• Omics-based approaches (e.g., transcriptomics, proteomics, spatial or multi-omics) and integration of molecular datasets
• Computational or bioinformatic analysis of biological data (preferred but not required)
• Rigorous experimental design, data analysis, and scientific reproducibility
• Excellent manuscript writing, presentation, and scientific communication skills This position offers the opportunity to lead innovative, translational research at the intersection of dermatology, regenerative medicine, and aging biology within a well-resourced academic medical center.
A Research Fellow position in Life Sciences (LS) will require knowledge of either clinical-based research or laboratory-based research often obtained from a postdoctoral program.
"A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Upon background check and CCATS Executive Committee approval, Research Fellow may have patient/research subject contact directly relating to and incidental to the original research program. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic."
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
Mayo Clinic has expanded and changed in many ways, but our values remain true to the vision of our founders. Our primary value – The needs of the patient come first – guides our plans and decisions as we create the future of health care. Join us and you'll find a culture of teamwork, professionalism and mutual respect, and most importantly, a life-changing career.
Mayo Clinic was founded in Rochester, Minnesota by brothers Dr. William James Mayo and Dr. Charles Horace Mayo. More than 100 years later, their vision continues to evolve around a single guiding value: "The needs of the patient come first." Today we are the largest integrated, not for-profit medical group practice in the world.
We are recognized for high-quality patient care more than any other academic medical center in the nation. These endorsements are very gratifying, but also humbling. They remind us of the tradition that has been entrusted to each one of us, and the legacy of excellence that we uphold every day.
