The Translational Neuroproteomics Laboratory (Rossoll Lab) is seeking a highly motivated Postdoctoral Research Fellow to join our Foundation-funded project to define the proteomic composition and molecular environment of pathological phospho-TDP-43 (pTDP-43) aggregates in human brain tissue and determine how these associated proteins contribute to neurodegeneration in sporadic frontotemporal lobar degeneration (FTLD-TDP).
The project integrates microscope-guided photolabeling/proximity proteomics in FFPE human brain tissue, affinity purification, data-independent acquisition LC-MS/MS, multiplexed spatial biology, proteomics data analysis, and functional validation in cellular and organotypic brain-slice culture models of TDP-43 proteinopathy.
The position offers an opportunity to work in a highly interactive neuroscience community at Mayo Clinic Florida, with access to world-class facilities, including the Multiomics Mass Spectrometry (MMS) core, and the Mayo Clinic brain bank.
Interested applicants should send a cover letter, CV, and contact information for three references to Dr. Wilfried Rossoll at rossoll.wilfried@mayo.edu.
Location: Jacksonville, Florida
Contact: Dr. Wilfried Rossoll — rossoll.wilfried@mayo.edu
More info: https://www.mayo.edu/research/labs/rossoll-lab
A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.
• Ph.D. (or equivalent) in Neuroscience, Cell or Molecular Biology, Biochemistry, or related field
• Strong background in molecular and cell biology techniques, biochemistry, and fluorescence microscopy
• Experience with tissue, cell culture, and proteomics is desirable
• Excellent organizational, communication, and teamwork skills
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