The Research Fellow will join a translational cancer biology and radiation research environment focused on mechanisms of treatment response and resistance. The emphasis on metabolism, stress-response signaling, DNA damage response, and therapeutic vulnerabilities that may be exploited to improve cancer treatment. The position will support laboratory and translational research projects involving radiation biology, metabolic perturbation, drug-radiation combinations, and biomarker-oriented studies using cell-based, molecular, biochemical, and potentially animal-model systems.
The candidate should be prepared to work in a collaborative academic laboratory setting with close interaction among basic scientists, physician-scientists, trainees, and technical staff. Responsibilities may include:
The role is best suited for a highly motivated postdoctoral researcher who can work independently while also coordinating closely with project mentors and collaborators.
Specific techniques and tasks may include; mammalian cell culture; irradiation experiments; clonogenic survival assays; proliferation, viability, and apoptosis/cell-death assays; drug-treatment and combination studies; Western blotting or related protein-analysis methods; qPCR or other gene-expression assays; immunofluorescence microscopy; flow cytometry when needed; metabolomics- or phosphoproteomics-adjacent sample preparation and interpretation; basic molecular biology; data organization and statistical analysis; and preparation of publication-quality figures. Depending on project needs and prior training, the candidate may also participate in in vivo tumor studies, tissue processing, immunohistochemistry, and coordination with institutional cores for omics, imaging, pathology, or animal work.
The work environment is a wet-lab research setting requiring careful adherence to laboratory safety, biosafety, radiation-safety, animal-research, and data-management policies. The candidate should be comfortable working with human or animal-derived biological materials when applicable, using shared equipment, coordinating with core facilities, and handling multiple active projects in a deadline-driven research environment.
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
Mayo Clinic has expanded and changed in many ways, but our values remain true to the vision of our founders. Our primary value – The needs of the patient come first – guides our plans and decisions as we create the future of health care. Join us and you'll find a culture of teamwork, professionalism and mutual respect, and most importantly, a life-changing career.
Mayo Clinic was founded in Rochester, Minnesota by brothers Dr. William James Mayo and Dr. Charles Horace Mayo. More than 100 years later, their vision continues to evolve around a single guiding value: "The needs of the patient come first." Today we are the largest integrated, not for-profit medical group practice in the world.
We are recognized for high-quality patient care more than any other academic medical center in the nation. These endorsements are very gratifying, but also humbling. They remind us of the tradition that has been entrusted to each one of us, and the legacy of excellence that we uphold every day.
