Job Description

A full-time postdoctoral fellow position is available in Dr Margaret M. Redfield’s lab within the Department of Cardiovascular Medicine at Mayo Clinic in Rochester, MN. Dr Redfield’s research program focuses on heart failure (HF) with preserved ejection fraction (HFpEF) and includes mechanistic and therapeutic studies in humans and large and small animal models of HFpEF and HF related pulmonary hypertension. Mechanistic studies include hemodynamics, cardiac and pulmonary histology and cardiac and pulmonary tissue discovery omics (RNA, proteomics, metabolomics, spatial omics and bioinformatics) from humans and animal models.

Key Responsibilities of this position include:

• Design and conduct experiments, including sample preparation, to characterize the molecular and metabolic signatures of large-animal and human HFpEF using multi-omics approaches.
• Perform bioinformatics analyses of sequencing datasets, including data processing, quality control, integration, and biological interpretation.
• Integrate multi-omics findings with histological, functional, and clinical phenotypes of large-animal models and human HFpEF subjects to elucidate disease mechanisms.

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Upon background check and CCATS Executive Committee approval, Research Fellow may have patient/research subject contact directly relating to and incidental to the original research program. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

• M.D. Ph.D. or Ph.D. in a relevant subject (cardiovascular medicine, physiology, molecular biology, etc.)
• Omics data acquisition and analysis (any of the following: RNA-seq, proteomics, spatial omics, metabolomics)
• Strong record of productivity and good publication record in peer-reviewed journals
• Strong personal skills, and excellent verbal and written communication skills – ability to work independently and as part of a team.
• Demonstrate independence in critical thinking and rigorous work
• Experience with large or small animal models, cardial and/or pulmonary histology and cardiovascular hemodynamic assessments would be desirable.

Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.