Postdoctoral research positions are available in the laboratory of Dr. Fabienne Fiesel to investigate pathogenic mechanisms of neurodegeneration at Mayo Clinic in Jacksonville, Florida.
The Fiesel lab studies molecular pathways that regulate tau biology and protein homeostasis, with a particular interest in UFMylation and how alterations therein contribute to Alzheimer’s disease and related neurodegenerative disorders. The lab employs a multi-disciplinary approach using state-of-the-art techniques in cell biology, biochemistry, imaging, and proteomics to illuminate the underlying disease biology in iPSC-derived cell models, in vivo in mice, and in human clinical and neuropathological specimens.
Specific research projects include
1) investigation of mechanisms regulating tau aggregation and propagation in Alzheimer’s disease and related tauopathies,
2) identification of UFM1-modified proteins and pathways using biochemical and proteomic approaches,
3) mechanistic studies of tau and UFMylation in iPSC-derived cells and mouse models, as well as
4) genetic and pharmacological modulation of UFMylation as a potential therapeutic strategy.
How to Apply: Qualified candidates should send a cover letter outlining research interests and achievements along with their curriculum vitae to Fabienne Fiesel (Fiesel.Fabienne@mayo.edu).
For an overview of research and laboratory visit: https://www.mayo.edu/research/labs/cellular-mechanisms-neurodegenerative-disorders/overview
Mayo Clinic and the Department of Neuroscience offer an outstanding research and training environment with a competitive stipend and a generous fringe benefit package.
Applications are invited from highly motivated candidates holding a recent Ph.D. or M.D./Ph.D. with a strong research background in neuroscience, cell biology, or biochemistry. Expertise in iPSC models, mouse work, imaging or proteomics approaches is desirable. In addition, qualified candidates should have a record of impactful, peer-reviewed publications. Excellent verbal and written communication skills in English are essential
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