Job Description

Key responsibilities for this position include:

• Establish in vitro disease models in relevant cell types including primary neurons and glia isolated from transgenic animal models and patient-derived iPSC lines. 
• Design, troubleshoot, and execute cell-based assays in human and rodent cell lines to characterize the efficacy and safety of company's novel tRNA therapeutic leads. 
• Understand mechanism of action of lead candidates and establish assays and endpoints relevant to downstream target and disease biology. Conduct literature searches; communicate understanding in internal forums and with external collaborators and partners. 

Minimum qualifications:

• A BS/MS in Neurobiology, Molecular/Cellular Biology, physiology, or a related discipline. 
• Extensive hands-on experience with a variety of molecular, cellular and/or physiological techniques (isolating rodent neurons and establishing primary neuronal cultures, neurite outgrowth, qPCR, western blotting, microscopy, calcium imaging, synaptic imaging, multi-electrode arrays, human IPS/ES cell culture, etc). 
• Prior experience using AAV/lentivirus in primary or iPSC-derived neurons is highly desirable. 
• Ability to master new concepts and technologies quickly and run experiments independently. 
• Scientifically rigorous, highly organized, with excellent oral and written communication skills. 
• Ability to work independently as well as collaborate with colleagues and effectively prioritize and manage multiple tasks in a fluid, fast-paced work environment