Job Description

Nuclera is a venture-backed, founder-driven biotech company headquartered in Cambridge, UK with significant operations in Boston, USA. The company’s mission is to improve human health by making proteins accessible. We are beginning this mission through the launch of our eProtein Discovery™ platform. eProtein Discovery is a breakthrough protein expression, characterization, and purification technology, consisting of a lab-based benchtop instrument, cloud-based software and proprietary cartridges and consumables. The goal is to enable rapid protein access to life science researchers around the world.

The successful candidate will be responsible for amplifying DNA constructs as well as delivering custom projects using our eProtein Discovery Platform in strict accordance with SOPs and work instructions. This position requires the ability to deliver under tight deadlines, attention to detail and strong organizational skills while working independently in a fast-paced environment. The ideal candidate will have a strong background in protein science, molecular biology, or a related discipline, with proven hands-on experience in an industry setting.

About the role

• Perform PCR to prepare DNA constructs for cell-free protein expression
• Carry out protein purification, quantification, SDS PAGE analysis and gel filtration chromatography or Surface Plasmon Resonance (SPR) analysis
• Execute experiments using Nuclera’s eProtein Discovery Platform
• Adhere strictly to Work Instructions and Standard Operating Procedures to ensure consistency and quality
• Systematically organize, track and manage large numbers of biological samples
• Accurately record and document experimental methods, observations and results

Requirements

Essential

• BSc in biochemistry, molecular biology, or a related discipline, with a minimum of 2 years’ industry experience
• Proven track record of generating reliable data and delivering results within tight deadlines
• Hands-on experience in molecular biology techniques including PCR, PCR clean-up and agarose gel electrophoresis
• Experience with protein science techniques, including affinity-based purification, protein quantification, SDS PAGE analysis
• Strong organizational skills
• Eligible to work in the UK

Desirable

• MSc in biochemistry, molecular biology, or related discipline, with a minimum 1 years’ industry experience
• Previous experience in a Contract Research Organization (CRO) and/or the biotechnology industry
• Familiarity with liquid handling platforms such as Opentron and KingFisher
• Experience using automated electrophoresis systems such as the Fragment Analyzer
• Understanding of the principles of cell-free protein synthesis technologies
• Prior experience using protein biophysical characterization techniques such as gel filtration chromatography
• Prior experience in expressing and purifying antibodies
• Prior experience using antibody functional characterization techniques such as Surface Plasmon Resonance (SPR)

Benefits

What we offer: In addition to competitive salaries, we offer a range of benefits including:

• Company bonus scheme of 5%
• Life insurance
• Private medical insurance and cash plan
• 25 days' annual leave + Bank Holidays
• Enhanced employer's pension contributions
• Enhanced maternity and paternity Leave
• Investment in professional development and learning
• Access to amenities on Vision Park and in Histon
• Fresh fruit, tea, coffee, and snacks in the office
• Organised team events