Job Description

Monte Rosa Therapeutics is seeking a motivated Contract Research Associate for 6 months to contribute to our mission of eliminating disease-causing proteins through targeted protein degradation, an innovative approach that enables us to target proteins once considered undruggable. The ideal candidate will have strong expertise in Cell and Molecular Biology, utilizing CRISPR techniques in a drug discovery setting. You will join a fast-paced and innovative team environment that values teamwork, collaboration, and scientific rigor.

Responsibilities

• Engineer mammalian cell lines by CRISPR technology (KI and KO) and lentiviral transduction.
• Culture a variety of cell lines and primary cells, testing compound-induced target degradation by Western Blot, JESS and plate-based assays
• Assess pathway modulation by using pharmacological and genetic target perturbation strategies.
• Keep meticulous records of experiments on ELN.

Qualifications

• B.S. or M.S. in Biotechnology, Molecular Biology, Genetics or related field with 1-3 years of industry experience.• Extensive experience with cell culture techniques including transient transfection, lentiviral transduction, CRISPR, NanoBiT and NanoBRET. Experience handling primary cells desired.• Experience with molecular biology techniques (ELISAs, Western Blot, PCR, vector design, sequencing analysis).• Immunology background is a plus.• Previous experience with lab automation and high throughput data management, analysis and visualization (e.g. Spotfire, CDD Vault, Genedata) is a plus.• Excellent oral and written communication skills.