Job Description

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Overview

Job Description:

Research Associate I will perform laboratory experiments and data analysis supporting studies of bone physiology using cellular, molecular, histological, flow cytometry, and animal-based techniques.

Responsibilities include animal husbandry and handling, FACS experimentation and analysis, tissue processing and staining, and analysis of large-scale experimental datasets.

Key Responsibilities

Design and conduct experiments using transgenic and wild-type mouse models of skeletal biology and disease.

Perform animal procedures, tissue harvest, and phenotypic characterization in accordance with IACUC protocols.

Utilize molecular and cellular techniques including PCR, qPCR, RNA and protein analyses, histology, immunohistochemistry, RNA in situ hybridization, cell culture, and microscopy.

Analyze bone structure and function using imaging modalities such as microCT and histomorphometry.

Interpret experimental data using appropriate statistical methods and prepare figures for publication.

Maintain detailed laboratory notebooks and ensure rigorous data management and reproducibility.

Prepare manuscripts, abstracts, grant applications, and presentations for scientific meetings.

Supervise and mentor graduate students, technicians, and trainees in laboratory techniques and experimental design.

Manage mouse colonies, laboratory inventories, reagent procurement, and shared equipment.

Required Skills and Abilities

1. Flow Cytometry (FACS): Demonstrated ability to perform flow cytometry experiments, including sample preparation, panel development, instrument operation, data acquisition, and analysis.
2. Animal Husbandry and Handling: Ability to safely and appropriately handle and maintain laboratory animals, including routine husbandry, genotyping, and preparation for experimental procedures in accordance with institutional guidelines.
3. Histology and Tissue Processing: Experience with tissue collection, fixation, processing, sectioning, and histological staining techniques for evaluation of bone and other tissues.
4. Large-Scale Data Analysis: Ability to organize, analyze, and interpret large datasets generated from experimental studies, with proficiency in relevant computational and statistical tools.
5. Wet-Lab Experimental Skills: Strong technical skills in molecular and cellular biology techniques, with the ability to independently perform experiments, troubleshoot protocols, maintain accurate records, and work effectively in a collaborative research environment.

Preferred Skills and Abilities

1. IACUC/Animal Research Training – Completion of institutional training in the ethical use, handling, restraint, and care of laboratory animals, including species-specific training for mice and/or rats.
2. CITI Program Training – Completion of applicable CITI Program courses in animal care and use, biosafety, and responsible conduct of research.
3. Laboratory Safety Training – Required institutional training in chemical hygiene, biosafety, bloodborne pathogens, hazardous materials, and laboratory safety.
4. Flow Cytometry/FACS Training – Documented training or demonstrated competency in flow cytometer operation, cell sorting, instrument maintenance, and FACS data analysis.
5. Animal Handling/Surgical Training – Completion of institutionally approved training for animal handling and, where applicable, anesthesia, injections, tissue collection, and other experimental procedures. A veterinary or professional animal-care license is generally not required for a Research Associate I unless the position specifically involves regulated veterinary duties.

Principal Responsibilities

1. Recommends the design and implementation of procedures and protocols under the direction of a higher-level authority. 2. Investigates, analyzes, and reaches preliminary scientific conclusions related to research planning 3. Ensures data results are compiled, analyzed, and presented properly. 4. Analyzes, develops and interprets scientific results. Maintains clear documentation of results. Prepares scientific reports and papers for research proposals and published reports. 5. Performs independent research and laboratory techniques and participates in experimental research planning. 6. Interacts with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and to ensure the smooth and safe operation of the laboratory. 7. Interacts with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and to keep abreast of product information and developments. 8. May perform other duties as assigned. Required Education and Experience Master’s Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.

Job Posting Date

10/27/2026

Job Category

Professional

Bargaining Unit

NON

Compensation Grade

Clinical & Research

Compensation Grade Profile

Research Associate 1 MS (22)

Salary Range

$61,500.00 - $91,875.00

Benefits

A general description of the benefits to be offered with this Managerial & Professional position is available at:

Yale Benefits

Time Type

Full time

Duration Type

Staff

Work Model

On-site

Background Check Requirements

All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website.

Health Requirements

Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy.

Posting Disclaimer

Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions.

The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the position. Employees will be assigned specific job-related duties through their hiring department.

The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.

Inquiries concerning Yale's Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA).

Note

Yale University is a tobacco-free campus.