Job Description

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients.

We are currently looking for a Principal Scientist to join our R&D team in our facility in Gent/Zwijnaarde. In this senior scientific leadership role, you will oversee part of our discovery pipeline from a biology perspective, making sure that the right biological questions are asked, and answered, at the right time. You will lead and develop scientists and their project teams through co-creation and empowerment rather than hierarchy. This all happens in a dynamic, informal and stimulating environment where you and your colleagues work to reach the set goals and co-develop novel therapeutics to bring to patients.

Work description

As Principal Scientist, you will hold scientific oversight of part of the argenx discovery pipeline, with a clear focus on the targeted disease and target biology. Rather than owning a single project, you will guide multiple project teams in shaping their workplans, setting priorities and taking well-founded decisions, ensuring that risks related to the targeted biology are identified early and addressed at the right moment in drug development. You will help shape the longer-term scientific direction of your area, contribute to the evaluation of new opportunities, and grow the next generation of scientific leaders.

Key responsibilities include:

• Biology Leadership across the Pipeline: Oversee and support part of the discovery pipeline as the scientific sparring partner of project teams on disease and target biology. Co-create and challenge workplans, help set priorities, and ensure that biology-related risks (e.g., mechanism of action, target expression and function, pathway redundancy, safety liabilities and translatability to patients) are recognized and addressed at the right time in drug development.
• Decision-Making & Prioritization: Guide project teams toward decision-enabling data packages and well-founded go/no-go decisions. Help balance speed with rigor, make trade-offs transparent, and bring in adjacent functions (e.g., Preclinical Product Development, Translational and Clinical Science, IP, Business Development) at the right moment.
• Immunology Innovation Program & Business Development: Support the scientific review of new project proposals coming in through argenx’s Immunology Innovation Program as well as external business development opportunities. Assess the strength of the underlying biology and its fit with argenx’s portfolio, and formulate clear, science-based recommendations.
• Scientific Direction: Contribute to the longer-term (3–5 year) scientific direction in your area by spotting emerging biology, capability gaps and new approaches that change what argenx is capable of, not only what it delivers in the short term.
• Developing Future Leaders: Lead and develop scientists and their project teams in a non-hierarchical, non-matrix organization. Coach colleagues on scientific judgement, biological depth, priority setting and stakeholder management, and actively identify, sponsor and grow the next generation of (senior) scientists, empowering them to take ownership rather than taking it over.
• Learning Transfer & Expert Network: Maximize learning transfer across projects and teams, connect project teams with essential internal stakeholders, and build a network of internal and external experts (key opinion leaders, academic groups, consortia) around the projects and the biology they target. Represent argenx in scientific forums and partnership discussions and bring those insights back inside.

Profile

• PhD in immunology or a closely related biomedical field, with at least 8 years of relevant research experience after your PhD, of which at least 6 years in project-based biotech or biopharmaceutical industry.
• Deep and broad immunological knowledge, spanning innate and adaptive immunity and the mechanisms of autoimmune and autoinflammatory disease, combined with a proven ability to go deep into novel biology fast and translate it into the right experimental and strategic questions.
• Solid understanding of the drug discovery and development process, and of how biology-driven choices made early impact later development.
• Track record of scientific leadership across multiple projects and of developing more junior colleagues, with a leadership style built on co-creation, empowerment and humility rather than hierarchy.
• Experience with therapeutic antibody discovery and engineering (e.g., Fab, Fc and format engineering, FcRn and FcγR biology) and with the evaluation of external opportunities is a plus; immunology depth remains essential.
• Recognized scientific credibility and excellent communication skills to challenge, influence and connect people constructively; fluent in English, our working language.

Offer

• A full-time position in a successful, dynamic, rapidly growing biotech company;
• A competitive salary package accompanied by comprehensive benefits;
• Joining a team that provides access to a wide range of technologies, engaging in diverse daily tasks, and encouraging initiative-taking to contribute to the company's success;
• Onsite presence 4 days per week is required to ensure effective team dynamics

Apply

Please upload your CV and a focused motivation letter (max. 2 pages). Rather than repeating your CV, use your letter to show us how you think and how you lead. We ask you to cover four points:

• Why this role, and why now – what attracts you to guiding the biology across a part of a pipeline rather than leading a single project, and what draws you to argenx specifically.
• A biology call that mattered – describe one situation where your reading of the disease or target biology changed the course of a project or the decision on an opportunity: the risk you saw, when and how it was addressed, who you involved, and what the outcome was.
• How you grow other leaders – give a concrete example of how you helped a colleague or team grow in scientific judgement and ownership without taking over: what you did, what they did, and what changed.

Application deadline is October 25, 2026

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The annual base salary hiring range for this position is €100,000.00 - €137,500.00 EUR

This job is eligible to participate in our short-term and long-term incentives program.

The hiring range displayed above is the range of possible base pay compensation that argenx believes in good faith it will pay for this role at the time of this posting. The hiring range is based on the job grade for this position. Individual compensation paid within this range depends on a variety of factors, including, but not limited to, internal equity, prior education and experience, job-related knowledge and demonstrated skills. argenx may pay more or less than the posted range and this range may be modified in the future.

At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.

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