Job Description

Principal Analytical Investigator II (PAI II)

Location: Colorado Springs, CO or Millcreek, UT (Optional Work From Home)

Compensation: $100,000–$130,000 annually

About the Opportunity

Lighthouse Lab Services is partnering with Aliri Bio to identify an experienced Principal Analytical Investigator II (PAI II) to support its growing bioanalytical laboratory operations. Aliri Bio provides specialized laboratory testing and scientific services to pharmaceutical and biotechnology companies, supporting drug development through advanced analytical testing and research.

The PAI II will provide scientific and operational leadership for bioanalytical studies, ensuring projects are completed efficiently, accurately, and in accordance with applicable regulatory requirements. This individual will serve as a key liaison between laboratory operations, quality assurance, reporting teams, and external clients while overseeing project execution, resource allocation, and client deliverables.

The ideal candidate will bring a strong background in analytical chemistry or bioanalysis, experience with regulated laboratory environments, and the ability to manage complex scientific projects while maintaining strong client relationships.

Key Responsibilities

• Oversee the planning, coordination, and execution of bioanalytical studies to ensure projects meet established timelines, budgets, and client expectations.
• Evaluate incoming projects for technical feasibility, laboratory capacity, staffing requirements, and resource availability.
• Coordinate cross-functional activities between laboratory operations, quality assurance, reporting, and other internal departments.
• Monitor project progress, laboratory productivity, and resource utilization to support organizational and monthly revenue goals.
• Serve as a primary point of contact for clients, providing regular project updates, managing expectations, and addressing questions or concerns.
• Provide scientific guidance throughout study execution, including experimental design, analytical data interpretation, and adjustments to study approaches as needed.
• Review technical data and ensure study results meet applicable internal, client, and protocol specifications.
• Oversee the preparation, review, and finalization of technical and regulatory study protocols, plans, and reports.
• Ensure studies are conducted in accordance with applicable regulatory guidelines, including GLP, CDER, CVM, ICH, FIFRA, and VICH requirements.
• Coordinate data reconciliation, report reviews, and study archival approvals.
• Identify opportunities to improve laboratory efficiency, productivity, and overall project execution.
• Collaborate with internal stakeholders to balance competing project priorities and ensure successful delivery of client programs.

Qualifications

• Bachelor's degree in Chemistry or a related scientific discipline with 8–10+ years of relevant experience; OR
• Master's degree in Chemistry or a related scientific discipline with 7+ years of relevant experience; OR
• Ph.D. in Chemistry or a related scientific discipline with 5+ years of relevant experience.
• Significant relevant professional experience may be considered in lieu of formal education.
• Strong technical understanding of analytical chemistry, bioanalysis, and laboratory operations.
• Proficiency in instrumental analysis, particularly mass spectrometry and chromatography.
• Experience working in GLP-regulated laboratory environments.
• Knowledge of applicable pharmaceutical, bioanalytical, and industry regulatory guidance.
• Experience managing scientific studies, reviewing analytical data, and preparing or reviewing technical reports.
• Strong project management, resource planning, and organizational skills.
• Excellent written and verbal communication skills, with demonstrated ability to manage client relationships.
• Ability to manage multiple projects and competing priorities in a fast-paced laboratory environment.

Preferred Qualifications

• Hands-on or oversight experience with mass spectrometry, LC-MS/MS, or HPLC.
• Advanced knowledge of Watson LIMS.
• Advanced Microsoft Excel skills.
• Previous experience in a pharmaceutical, biotechnology, or contract research laboratory (CRO).
• Experience supporting bioanalytical development programs and regulatory submissions.

Work Environment

• Based in Colorado Springs, CO or Millcreek, UT, with optional work-from-home flexibility.
• Primarily office-based with occasional exposure to laboratory environments.
• No routine travel required.
• Occasional extended hours or weekend work may be necessary during peak production periods.

Compensation & Benefits

• Annual salary range of $100,000–$130,000, depending on experience and qualifications.
• Additional benefits and employment details to be discussed during the interview process.

About Lighthouse Lab Services

Lighthouse Lab Services specializes in connecting laboratory professionals with opportunities across clinical diagnostics, public health, pathology, and laboratory operations. Our team works with laboratories nationwide to recruit qualified professionals for contract and permanent positions.

If you have a background in laboratory safety, chemical hygiene, environmental health and safety, or occupational safety and are looking for an opportunity to make a meaningful impact in a complex laboratory environment, we encourage you to apply.

Apply today to learn more about this opportunity.

#LLS2