Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.
Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.
Our two Institute Initiatives reflect this model in action:
More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.
We are seeking a Postdoc to join the Pluvinage Lab at the Arc Institute. Our goal is to improve the lives of patients with neurological diseases. We do this by exploring undiagnosed autoimmunity in rare mystery cases and common neurodegenerative conditions alike. Starting with clinical observations and primary patient tissue, we use functional genomics, protein display technologies, and computational tools to embark on deep mechanistic dives into the contribution of autoimmunity to cognitive function. Your work will have the potential to uncover novel autoantibodies that drive cognitive decline in autoimmune encephalitis, that modulate cognitive decline in dementia, and that promote cognitive resilience in healthy brain aging.
The questions we ask:
The approaches we take: discovery-driven projects starting with human samples (cerebrospinal fluid, PBMCs, brain tissue) from curated cohorts of patients with neurological diseases, CRISPR screens, phage display, immune repertoire sequencing
Postdocs will be encouraged to lead independent projects resulting in high impact publications, present at conferences, and prepare for long-term careers in academia or industry. Clinical residents or fellows interested in physician-scientist pathways are encouraged to apply.
Please submit:
The minimum base salary for this position is $80,000. Base salary for this role is determined by how many months of relevant postdoctoral experience a successful candidate has. Base salary for this role is not negotiable.
Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development.
Headquartered in Palo Alto, California, Arc is a non-profit organization founded on the belief that many important research programs will be enabled by new academic models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.
As individuals, Arc researchers collaborate across diverse disciplines to study complex diseases, including cancer, neurodegeneration, and immune dysfunction. As an organization, Arc strives to enable long-term research agendas by betting on people rather than projects, and making it easier to invent and deploy new technologies at scale.
Together, our mission is to accelerate scientific progress, understand the root causes of disease, and narrow the gap between discoveries and impact on patients.
