A postdoctoral training position is available in the laboratory of Dr. Benjamin Sabari, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to understand how biomolecular condensates organize gene regulation. Our laboratory has the overarching goal to understand how the machinery required for gene activation is organized within the nucleus in healthy and diseased cell states. The process of gene activation requires hundreds of unique proteins and RNAs that must engage with specific DNA elements to position RNA Polymerase at a gene for transcription. We study the role of dynamic compartments called biomolecular condensates in organizing the transcriptional machinery. We investigate how nuclear condensates form at specific genomic loci, how they function to compartmentalize biochemistry, and how they are dynamically regulated. The lab focuses on the roles of protein disorder, regulatory DNA element clustering, and active processes in the formation and function of nuclear condensates. We investigate these processes in various biological contexts including adipogenesis, stem cell differentiation, and cancer.
Candidates must hold a recent Ph.D. and/or M.D. degree. Experience in any of the following areas: live cell microscopy, in vitro biochemistry, proteomics and epigenomics.
Interested individuals must upload a CV
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.
This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.
Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.
To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/
