Postdoctoral Researcher (f/m/x) Biology (Life Sciences) for Preclinical Imaging

• Planning, conducting and analyzing the biological evaluation of newly developed PET and SPECT radiotracers
• Contributing to the establishment, optimization and
  documentation of biological test systems and preclinical evaluation protocols
• Performing in vitro studies, including stability, binding and cellular uptake assays as well as studies using models of the blood-brain-barrier
• Preclinical evaluation of tracer candidates in suitable in vivo models, including support of small-animal imaging studies
• Performing and analyzing ex vivo studies, e.g., autoradiography, biodistribution studies and complementary tissue analyses
• Quantitative analysis of biological and imaging data and
  interpretation of results in close interaction with the other project partners
• Evaluation, documentation, and scientific presentation of experimental results in project reports, publications, and presentations

• Completed university degree and Ph.D. in biology, life
  sciences, neuroscience, biochemistry, pharmacy or a related field
• Experience in preclinical imaging (e.g. small animal PET,
  SPECT, MRI, CT)
• Experience with animal models and experimental animal work is advantageous (FELASA-B or EU functions A, C, D)
• Experience with cell culture, in vitro assays, autoradiography, ex vivo analyses and BBB models is desirable
• Interest in radiopharmaceutical tracer development, molecular imaging and translational research
• Willingness to work with unsealed radioactive substances and to become familiar with radiation protection-related workflows
• Willingness to conduct biological and preclinical experiments within an interdisciplinary team
• Good written and spoken English skills
• Structured, independent and conscientious working style
• Ability to work in a team, strong communication skills and interest in interdisciplinary collaboration between chemistry, radiochemistry, biology, medicine and imaging

• Everything but ordinary: You can expect a secure job in a challenging, innovative environment – including company pension schemes and regular working hours without business trips.
• Work-life balance: Whether full-time or part-time, with or without children – with numerous support options, we will find the right path together.
• Team spirit in R(h)ine culture: You will be warmly welcomed by an interdisciplinary team that values mutual respect and helpfulness.
• Strong perspectives: We offer extensive training opportunities – so you can continuously grow and set new goals.

The Institute of Radiochemistry and Experimental Molecular Imaging (IREMB) is seeking a postdoctoral researcher for a translational research project in the field of radiopharmaceutical tracer development and molecular imaging. The postdoc position will initially be embedded for one year in the internationally funded IMAGESTRO project. There is an option of extension for another year. The focus of the work will be on the biological validation of newly developed PET or SPECT radiotracers.
The IMAGESTRO project aims to develop novel 18F-labeled PET tracers for the non-invasive imaging of estrogen receptors in the brain, to characterize them preclinically, and to translate them into human applications. The project focuses on the organic synthesis of suitable precursor and reference compounds, the development and optimization
of radiofluorination strategies, and the comprehensive analytical and preclinical characterization of the resulting radiotracers. The work will be carried out in close cooperation between the University Hospital Cologne and Forschungszentrum Jülich and offers an interdisciplinary research environment at the interface of organic chemistry, radiochemistry, radiopharmacy, molecular imaging, biology and neuroscience.

Univ.-Prof. Dr. Bernd Neumaier
Tel.: +49 221 478-86807