Job Description

A postdoctoral position is available in the laboratory of Samuel W. Brady.

The lab focuses on identifying and therapeutically targeting key dependencies in pediatric solid tumors (Banu et al., Science Advances 12:eaeb3503 (2026) http://www.science.org/doi/10.1126/sciadv.aeb3503 and cancer genomics, including mutational signatures (Brady et al., Cancer Discovery 2026 http://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-0231/783733/Therapy-related-mutational-signatures-in

This position involves the experimental study of key pediatric cancer dependencies, and the identification of new approaches to target them therapeutically. This includes studies of protein signaling, subcellular relocalization, pharmacological studies using existing small molecule inhibitors, and the study of newly-developed compounds and approaches to inhibit essential childhood cancer dependencies. With a general background in cancer biology, pharmacology, and/or chemical biology, the ideal candidate would be familiar with cancer models, protein analysis (such as Western blot and immunoprecipitation), microscopy, cell culture, and molecular biology techniques. This position may also involve the experimental study of mutational signatures in pediatric cancer.

We are seeking an ambitious, proactive, and creative postdoctoral fellow with a strong interest in basic and translational cancer research. Applicants should have a recent PhD degree. This position is experimental, and will involve interfacing with computational genomics colleagues in the lab.

St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of catastrophic childhood diseases, including cancer. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment.

To apply, please submit a brief cover letter describing your research interests, goals, and how these align with the research in the laboratory, your CV, and contact information for 3 references.

St. Jude is an Equal Opportunity Employer

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