ST. LOUIS, MO 63110
The Kroll laboratory is seeking Postdoctoral Research Associates to spearhead new investigations expanding upon our core research programs in human cortical development and neurodevelopmental disorders (including autism spectrum disorder, intellectual disability, epilepsy, and brain overgrowth syndromes).
Fellows will drive independent projects leveraging our established human pluripotent stem cell (hPSC) differentiation pipelines—utilizing patient-derived iPSCs, patterned brain organoids, and assembloids—alongside our multi-omics, high-content imaging, and HD-MEA functional assessment platforms. Successful candidates will collaborate closely with team members to uncover transcriptional and epigenetic mechanisms governing GABAergic interneuron and excitatory neuron specification.
The Kroll laboratory focuses on defining transcriptional and epigenetic regulatory networks that build the human cerebral cortex, and how disruption of these programs causes neurodevelopmental disorders including autism spectrum disorder, intellectual disability, and epilepsy. We study how cortical neural progenitors are specified and initiate neurogenesis, and how the two major classes of cortical neurons, glutamatergic excitatory neurons and GABAergic inhibitory interneurons, differentiate, mature, and assemble into functional networks.
To study these processes in human cells, we use directed differentiation of human pluripotent stem cells (hPSCs), including genome-edited and patient-derived induced pluripotent stem cells (iPSCs), into cortical excitatory and inhibitory neurons and patterned brain organoids and assembloids. We combine these models with genome-wide approaches including defining changes in genome-wide transcription factor occupancy and histone modification state by CUT&RUN/Tag, RNA-seq, high-content imaging, and functional neuronal network assessment by high-density multi-electrode array. We also work with complementary mouse models to study aspects of neurodevelopmental disorders.
Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.
Lab Website: https://sites.wustl.edu/krolllab/.
Trains under the supervision of a faculty mentor including (but not limited to):
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience.
Please submit a cover letter, CV, and contact information for three references.
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.
Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree. - Molecular Genetics And Genomics
No specific certification/professional license is required for this position.
No specific work experience is required for this position.
Bioinformatics, Biological Sciences, Biology, Cell Biology, Genomics, Informatics, Life Science, Molecular Biology
A driver's license is not required for this position.
No additional education unless stated elsewhere in the job posting.
No additional certification/professional licenses unless stated elsewhere in the job posting.
No additional work experience unless stated elsewhere in the job posting.
Collaboration, Data Analysis, Data Interpretations, Experimentation, Laboratory Operations, Laboratory Techniques, Researching, Results Reporting, Scientific Writing
For frequently asked questions about the application process, please refer to our External Applicant FAQ.
If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans’ Readjustment Assistance Act of 1974 (VEVRAA), as amended.
