A postdoc position is available immediately in the laboratory of Dr. Daniel Blair which focuses on leveraging high-throughput chemical synthesis and MS/MS analysis to create predictive models of chemical reactivity.
Substrate aware reaction condition prediction
This project seeks to capitalize on our recent development of rapid tandem mass-spectrometry methods to scout chemical reaction outcomes ( Nature 2024, JACS 2026, Nature Protocols 2026). The proposed data rich experimentation will connect chemical structures to optimal reaction conditions. A competitive candidate will have a background in synthetic organic chemistry, experience with either automated synthesis or high-throughput experimentation is desirable. The project will be executed in the Department of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital and builds on strong investments into a world-class infrastructure in high-throughput chemical synthesis and analysis.
Please direct queries and application packets including a cover letter, current CV, and contact information for 3 referees to Dr. Daniel Blair (daniel.blair@stjude.org).
Papers/Links
U Neelakantan, … D J Blair* Generalized Analysis of Electrophilic Small Molecules, ChemRxiv 2026 doi: 10.26434/chemrxiv.10001482/v1
M Hu*, D J Blair* High-throughput reaction screening using acoustic ejection mass spectrometry, Nature Protocols 2026 doi: 10.1038/s41596-025-01320-y
M Hu, … D J Blair* Direct-to-Biology Enabled Molecular Glue Discovery JACS 2026
doi: 10.26434/chemrxiv-2025-4d7nq
M Hu… D J Blair* Continuous Collective Analysis of Chemical Reactions Nature 2024
doi: 10.1038/s41586-024-08211-4
https://www.science.org/content/blog-post/real-high-throughput-chemistry-through-mass-spec
Minimum Experience
PhD in Organic Chemistry
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