Job Title
Postdoctoral Research Associate
Agency
Texas A&M University Health Science Center
Department
Ibt - Cedp - Dashwood
Proposed Minimum Salary
$5,084.00 monthly
Job Location
Houston, Texas
Job Type
Staff
Our Commitment
Texas A&M University is committed to enriching the learning and working environment by promoting a culture that respects all perspectives, talents& livedexperiences. Embracing varying opinions and perspectives strengthens ourcorevalueswhich are: Respect, Excellence, Leadership, Loyalty, Integrity, and Selfless Service.
Who we are
As one of the fastest-growing academic health centers in the nation, Texas A&M Healthencompasses five colleges andnumerouscenters and institutes working together to improve health through transformative education, innovativeresearchand team-based health care delivery.
What we want
The Postdoctoral Research Associate will be involved in the identification of epigenetic and immunoepigenetic combination treatments that upregulate the MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy. The position will support translational cancer prevention studies using cell-based systems, primary cultures, 3D spheroid/organoid models, molecular assays, immunological assays, and rodent tumor models
What you need to know
Salary:Will becommensuratebased on the selected hire’s education and experience
Location/Schedule: Houston, TX/Full-Time
Apply! Submitting a cover letter, CV/Resume toassistus with the review process. You may upload these documentsonthe application under CV/Resume.
Required Education and Experience
MD/PhD in biochemistry, cell biology, immunology, cancer biology, pharmacology, molecular biology, or a related biomedical science field.
Preferred Qualifications
Experience with cancer biology, molecular biology, cell culture, and animal cancer models.
MD/PhD with experience in translational cancer biology, cancer prevention, immunology, epigenetics, or related biomedical research. Animal cancer models, primary tissue culture, 3D spheroid/organoid cultures, molecular biology, protein biochemistry, and immunology assays.
Epigenetics, HDAC biology, host immune surveillance, antigen-presentation pathways, immunoproteosome assays, with technical expertise of FACS, RNA-seq, Co-IP, ChIP, and T-cell co-culture systems.
Experience in performing rodent tumor studies under approved IACUC protocols, including oral gavage, intra-venous, intra-peritoneal and subcutaneous injections
Experience with antibody development, hybridoma screening, ELISA-based assays, and antibody characterization.
Clinical or translational research background, including MD training or experience connecting preclinical findings to human disease relevance, is preferred.
Knowledge, Skills, and Abilities
Ability to multi-task and work cooperatively with others.
Must be literate in the English language and be able to comprehend and follow effectively both written and verbal instructions.
Excellent interpersonal, oral and written communication skills in English.
Ability to do independent research in areas related to cancer immunology and epigenetics.
Ability to maintain accurate records, analyze data, prepare figures and reports, and contribute to manuscripts and presentations.
Responsibilities
Transcriptional and epigenetic regulation of MHC
Identification of epigenetic and immunoepigenetic combination treatments that upregulate MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy.
Studies may include HDAC-related mechanisms, immunoproteasome regulation, antigen-presentation pathways, and immune-response biomarkers.
Molecular, cellular, and biochemical work
Design and execute experiments involving epigenetic analyses, immunological assays, and molecular biology, protein biochemistry, and cancer prevention models.
Experimental procedures may include tissue culture, primary cell culture, 3D spheroid/organoid culture, co-IP, ChIP, PCR, qPCR, flow cytometry/FACS, Western blotting, ELISA, HDAC activity assays, fluorescence microscopy, and related in vitro assays using wild-type and genetically modified/null cell lines.
Rodent work and preclinical tumor models
Conduct rodent studies according to approved protocols and the highest ethical standards.
Participate in breeding and genotyping. Carefully monitor and record rodent well-being and morbidity.
Perform endoscopies and polypectomies on live rodents.
Perform necropsies and collection of organs for H&E, molecular, and immunohistochemical work.
Administer drugs/compounds to study animals via intra-oral, intra-venous, intra-peritoneal or subcutaneous routes.
Collaborations & presentations
Participate actively in weekly lab meetings within the center, and with other internal and external collaborators.
Participate in joint projects involving faculty, postdoctoral fellows, students, technicians, and core facility personnel.
Assist with training graduate students and junior lab personnel.
Support antibody core-related activities, including hybridoma screening, ELISA-based assays, and antibody characterization.
Assist with research grant proposals, conference abstracts, manuscripts, figures, tables, and timely publishable reports.
Conduct literature searches and contribute to new experimental approaches with rigor and reproducibility.
Why Texas A&M University?
We are a prestigious university with strong traditions, Core Values, and a community of caring and collaboration. Amenities associated with a major university, such as sporting and cultural events, state-of-the-artrecreation facilities, the Bush Library and Museum, and much more await you. Experience all that a big city has to offer but with a reasonablecost-of-living and no long commutes.
Medical,prescription drug,dental,vision,life and AD&D,flexible spending accounts, and long-term disability insurancewith Texas A&M contributing to employee health and basic life premiums
12-15 daysof annual paid holidays
Up to eight hours of paid sick leave and at least eight hours of paid vacation each month
Automatic enrollment in the Teacher Retirement System of Texas
Health and Wellness: Free exercise programs and release time
Professional Development: All employees have access to free LinkedIn Learning training, webinars, and limited financial support to attend conferences, workshops, and more
Educational release time and tuition assistance for completing a degree while a Texas A&M employee
Living Well,a program at Texas A&M that has been built by employees, for employees
Instructions to Applicants:Applications received by Texas A&M University must either have all job application data entered, or a resume attached. Failure to provide all job application data or a complete resume could result in an invalid submission and a rejected application. We encourage all applicants to upload a resume or use a LinkedIn profile to prepopulate the online application.
All positions are security-sensitive. Applicants are subject to a criminal history investigation, and employment is contingent upon the institution’s verification of credentials and/or other information required by the institution’s procedures, including the completion of the criminal history check.
Equal Opportunity/Veterans/Disability Employer.
