The Locci lab studies T cell-B cell collaborations in health and disease ( https://www.loccilab.com/). Areas of active investigation in the lab include T follicular helper (Tfh) cell differentiation and regulation of B cell responses in vaccination, infection, and autoimmunity in mice and humans. The Lab is part of the Institute for Immunology and Immune Health (I3H), a large and vibrant immunology community at the University of Pennsylvania (Philadelphia, USA).
We are seeking a motivated and talented postdoctoral researcher to lead a project aimed at dissecting the mechanism of Tfh cell and germinal center induction by mRNA-LNP vaccines. Qualified applicants should hold a PhD or an MD, possess a strong background in immunology, and have experience with in vivo mouse work, high-parameter flow cytometry, and confocal microscopy. Previous experience with mass spectrometry and bioinformatic skills is highly desirable.
Publications highlighting previous work from our group are:
- Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses. Castano, Bettini et al. Cell 2025
- Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer et al. Cell 2022
- Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh et al Immunity 2021
Applicants should submit a curriculum vitae, a cover letter, and contact info for two references
Foreign national postdocs are eligible to apply.
Qualified applicants should hold a PhD or an MD, possess a strong background in immunology, and have experience with in vivo mouse work, high-parameter flow cytometry, and confocal microscopy. Previous experience with mass spectrometry and bioinformatic skills is highly desirable.
Applicants should submit a curriculum vitae, a cover letter, and contact info for two references
The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.
