The Di Stefano Laboratory at Baylor College of Medicine is seeking a highly motivated Postdoctoral Associate to investigate the molecular mechanisms governing hematopoietic stem cell (HSC) fate and leukemogenesis. The research focuses on the intersection of post-transcriptional gene regulation, stem cell biology, and cancer.

The Di Stefano Lab employs cutting-edge genomic and molecular approaches that includes ribosome profiling, eCLIP-seq, and single-cell multiomics—to define gene regulatory networks at systems-wide scale. This project will investigate how RNA helicases and biomolecular condensates regulate hematopoiesis and leukemia using innovative degron mouse models and RNA recording technologies. The Postdoctoral Associate will have the opportunity to shape an emerging research direction that integrates fundamental RNA biology with translational cancer research.

The laboratory is embedded within the Stem Cells and Regenerative Medicine Center at Baylor College of Medicine and offers a highly collaborative and interdisciplinary environment. Trainees are strongly supported in developing independent research programs, and laboratory alumni have successfully transitioned into leadership roles in academia and biotechnology. The Postdoc is deeply committed to mentorship, scientific rigor, and professional development.

Baylor College of Medicine, located in the heart of the Texas Medical Center in Houston, offers world-class core facilities and a vibrant scientific community. Postdoctoral Associates receive competitive stipends and comprehensive benefits.

Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates.

For more information: https://www.bcm.edu/people-search/bruno-di-stefano-67886

Job Duties

• Designs and executes research investigating RNA regulatory mechanisms in HSCs and leukemia models.
• Utilizes and develops novel degron mouse models for functional genomics.
• Collaborates with a multidisciplinary team of computational biologists and clinical investigators.
• Communicates findings through high-impact publications and international conferences.
• Performs other job-related duties as assigned.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Ph.D. or M.D./Ph.D. in molecular biology, genetics, or a related biomedical discipline.
• Recent PhD graduates or those who have completed their PhD within the last three years at the time of application.
• Expertise in hematopoiesis, HSCs, or leukemia biology is strongly preferred.
• Experience with mouse models and flow cytometry (FACS) is highly desirable.
• A track record of scientific productivity as evidenced by peer-reviewed publications or preprints.