Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat.
Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un socle de recherche fondamentale. Le CEA s'engage depuis plus de 75 ans au service de la souveraineté scientifique, technologique et industrielle de la France et de l'Europe pour un présent et un avenir mieux maîtrisés et plus sûrs.
Implanté au cœur des territoires équipés de très grandes infrastructures de recherche, le CEA dispose d'un large éventail de partenaires académiques et industriels en France, en Europe et à l'international.
Les 20 000 collaboratrices et collaborateurs du CEA partagent trois valeurs fondamentales :
2026-41669
The Laboratory of Chemistry and Biology of Metals (LCBM) is a joint research unit (UMR 5249) affiliated with the French Alternative Energies and Atomic Energy Commission (CEA), the French National Centre for Scientific Research (CNRS), and Université Grenoble Alpes (UGA). It is located within the Grenoble Institute for Interdisciplinary Research (IRIG). The scientific research program of the LCBM, at the interface between chemistry and biology, focuses on studying the structure, activity, and regulation of complex biological systems that transport and use metal ions, as well as on leveraging this knowledge to develop bio-inspired systems with similar structures and/or functions. It is a research center dedicated to the study of the “chemistry and biology of metals,” with a unique critical mass and scientific coherence at both the national and international levels. The researchers at the LCBM develop multidisciplinary approaches to address three major societal challenges: the energy transition, reducing environmental impacts, and health. The research themes, which define the laboratory's teams, are Biocatalysis (BioCat); Physical Chemistry of Metals in Biology (PMB); Bioinorganic Catalysis and Environment (BioCE); Proteomics for Microbiology, Immunology and Toxicology (ProMit); Solar Fuels, Hydrogen and Catalysis (SolHyCat); Metals and Organs (MET&OR); Bioenergy & Environment (BioCE); and Computational Chemistry, Modeling and X-rays (CoMX).
Biologie, biophysique et biochimie
Post-doctorat
Post-doctorant en biochimie des métalloprotéines H/F
Projet REPAROX - PEPR
30
The REPAROX project aims to understand and harness repair mechanisms of [Fe-S] enzymes, key biocatalysts in biotechnology whose production and activity are severely limited under aerobic conditions, and translate this mechanism through an ab initio design approach to iron–sulfur biocatalysts of biotechnological interest.
The project builds on the recent discovery of a novel [Fe-S] repair mechanism, involving:
. An intrinsic component linked to the structure of the Quinolinate synthase NADA enzyme
. An extrinsic component associated with the mitochondrial environment
The project combines: Genetics, Molecular biology, Structural biology, Biochemistry, Spectroscopy, Computational protein design, and engineering metabolic pathways in yeast
IMPACT: REPAROX aims to overcome a major bottleneck in the aerobic bioproduction of [Fe-S] enzymes, enabling the development of more robust and tailor-made biocatalysts for industrial applications.
Within the REPAROX project, the BioCat team in Grenoble aims to biochemically, enzymatically, and spectroscopically characterize NadA from several organisms, both as an isolated enzyme and in complex with the protein partners involved in its repair mechanism under oxidative conditions.
Formation : PhD in biochemistry
Compétences : The candidates should have a strong expertise in biochemistry and enzymology and an interest for spectroscopy, structural biology and metals in biology. Candidates should preferably have a 2 to 4 years research experience
Expériences et activités sur place : expression and purification of proteins, enzymatic assay, metal content determination, biophysical characterization (SEC-MALLS, CD, Mössbauer and EPR spectroscopy, BLI (protein-protein interaction)).
Conformément aux engagements pris par le CEA en faveur de l'intégration des personnes handicapées, cet emploi est ouvert à toutes et à tous. Le CEA propose des aménagements et/ou des possibilités d'organisation pour l'inclusion des travailleurs handicapés
Grenoble
France
Grenoble
Autre
PhD in biochemistry
16/11/2026
The CEA is the French Alternative Energies and Atomic Energy Commission ("Commissariat à l'énergie atomique et aux énergies alternatives"). It is a public body established in October 1945 by General de Gaulle. A leader in research, development and innovation, the CEA mission statement has two main objectives: To become the leading technological research organization in Europe and to ensure that the nuclear deterrent remains effective in the future.
The CEA is active in four main areas: low-carbon energies, defense and security, information technologies and health technologies. In each of these fields, the CEA maintains a cross-disciplinary culture of engineers and researchers, building on the synergies between fundamental and technological research.
The civilian programs of the CEA received 49% of their funding from the French government, and 30% from external sources (partner companies and the European Union).
The CEA had a budget of 4,3 billion euros.
The CEA is based in ten research centers in France, each specializing in specific fields. The laboratories are located in the Paris region, the Rhône-Alpes, the Rhône valley, the Provence-Alpes-Côte d'Azur region, Aquitaine, Central France and Burgundy. The CEA benefits from the strong regional identities of these laboratories and the partnerships forged with other research centers, local authorities and universities.
