Plume is a passion-fueled, mission-driven company that is trans-founded with a vision to transform healthcare for every trans life. We hope to make gender-affirming hormone therapy easily accessible at the touch of a button in every state of the US.
This work is deeply personal and heart-driven, and we want teammates who care about the mission and the people we serve. For the right candidates, we present a rare opportunity to do well by doing good. Plume offers an affirming, trans-centered, culturally inclusive, and fun work environment filled with purpose.
As a part-time Nurse Practitioner with Plume, you will join our incredible team of diverse clinicians who provide GAHT (gender-affirming hormone therapy) and Expanded Clinical Services for our patients throughout the United States.
This is a part-time patient care position in which you will provide longitudinal care for a panel of patients. Your time will be spent onboarding new patients and providing follow-up care for them (lab management, prescription management, answering clinical questions). We have a large support team that takes care of patient account logistics so you can focus on clinical care.
This is a completely online, work-from-home role. We are a healthcare startup, so we are seeking folks excited about changing the paradigm of medical care so patients and clinicians are truly centered. We heavily leverage technology, so being comfortable with computers and electronic medical record systems in a rapidly changing environment is critical to doing this work.
We are specifically seeking Nurse Practitioners with California, Colorado, DC, Iowa, Kentucky, Massachusetts, Maine, Michigan, Oklahoma, Rhode Island, and Wyoming licenses. Bonus points if you have Connecticut, Indiana, New Jersey, and Ohio!
Applications for this role will be accepted until the role is filled or until 10/24/2026. Qualified applicants may begin the interview process before the closing date.
Everyone associated with Plume gets the major benefit of having the best coworkers you could imagine if you love fiercely intelligent, heart-forward, and mission-driven collaborators.
Plume is an equal-opportunity employer. Trans and gender-nonconforming individuals are strongly encouraged to apply, particularly those who identify as People of Color. We positively encourage applications from suitably qualified and eligible candidates regardless of age, color, disability, national origin, ancestry, race, religion, gender, sexual orientation, gender identity and/or expression, veteran status, genetic information, or any other status protected by applicable law. We will provide reasonable accommodations to individuals with disabilities upon request. Please let us know if you require any accommodations to apply or interview for this position.
Only those legally authorized to work in the USA are eligible to apply; residency in the USA is a requirement of employment for this role.
Discover more about Plume at www.getplume.co and become part of our award-winning journey towards transforming healthcare for every trans life. Join us today in shaping the future of healthtech and LGBTQ+ care!
Please be aware that employment scams are on the rise. Plume will only contact candidates using an official "@getplume.co" email address. Plume does not conduct interviews via email and will never request banking information through text or email. Please protect your information!
We’re so grateful for your interest in joining our team! To help us keep our operations running smoothly and ensure fair consideration for all candidates, we kindly ask that you refrain from reaching out to staff members directly regarding open roles.

Plume Clinic provides accessible, gender-affirming care designed by and for trans and gender-diverse adults. Our trans-led team offers trusted medical care, peer support groups, and educational events—all accessible from your phone. Whether you’re starting your transition or have been on your journey for years, we’re here to support trans people every step of the way. Join us in transforming healthcare for every trans life.