Job Description

The START Center for Cancer Research (“START”) is the world’s largest early phase site network, fully dedicated to oncology clinical research. Throughout our history, START has provided hope to cancer patients in global community practices by offering "Hope Through Access” to cutting edge trials throughout the United States and Europe.  

We are seeking a Clinical Principal Investigator. The Clinical Principal Investigator (PI) is a physician-scientist responsible for the overall preparation, conduct, and management of sponsored projects, ensuring compliance with all regulatory requirements and institutional policies. This role will manage the development and execution of clinical trial protocols, contribute to data analysis, and maintain strong communication and alignment with sponsors.

Schedule: M-F 8a-5p

Location: 125 Queens Rd. Charlotte, North Carolina 28204

Essential Responsibilities

• Manage early phase clinical trials by providing overarching medical direction and comprehensive medical reviews of protocols in conformance with the investigational plan and good clinical practice.
• Provide medical and scientific feasibility of all new sponsor inquiries driving growth through strategic partnerships.
• Lead and manage a matrix team of responsible for responsible for the conduct of early phase oncology trials.
• Ensure the safety and well-being of all participants in the study at the trial site are protected.
• Ensure data collected at the study site is credible and accurate.
• Ensure the rights, integrity, and confidentiality of all participants in the trial at the site are protected.
• Develop close personal working relationships with Sponsors and Clinical Research Organizations involved in study conduct.
• Provide expert guidance and support to clinical operations research staff and sponsor client.
• Lead continuous quality improvement efforts for clinical research services, integrating best practices and fostering a culture of research excellence.
• Develop and implement strategies to enhance patient recruitment and retention in clinical trials.

Required Education and Experience:

• M.D. or equivalent.
• Board Certified in Hematology and/or Medical Oncology.
• Clinical trials experience with a strong interest in drug development.
• Ability to critically analyze clinical scientific data and literature.
• Understanding of GCP principles, safety and adverse event reporting, FDA regulations, and biomedical research ethics.
• A passion for providing excellent clinical care and for working in a collaborative / team-oriented environment.

Preferred Education and Experience:

• Previous experience with industry sponsored clinical trials.
• Excellent communication skills, with experience in publishing and presenting at scientific meetings.
• Translational research experience and familiarity with pharmacokinetics and pharmacodynamics.

Potential applicants should directly contact Mary Vidovich (Mary.Vidovich@startresearch.com) or Chris H. Takimoto, MD, PhD (chris.takimoto@startresearch.com) at START Research

Best-in-Class Benefits and Perks 

We value the time, talent, and dedication our employees bring to START. Our commitment to your well-being and growth is reflected in a competitive compensation package—based on experience—along with comprehensive benefits designed to support you both personally and professionally: 

• 401(k) retirement savings plan with employer match 
• Eligibility for an annual performance bonus, based on role and company results 
• Generous paid time off and paid holidays 
• Comprehensive medical, dental, and vision coverage and optional insurance options 
• Company paid life and disability insurance for added financial protection 
• Employee Assistance Program (EAP) providing confidential, no ‑cost support for you and your family from day one 
• Flexible FSA and HSA plans to support your financial wellness 
• Commitment to a supportive environment that values balance, wellbeing, and flexibility 
• We’re committed to fostering a collaborative, creative workplace where every team member is encouraged to contribute. At START, you’ll join a team that values continuous learning, professional growth, shared ideas, and a culture built on inclusivity and innovation. 

More About START 

START clinical trial sites have conducted more than 1,000 early-phase clinical trials, including dozens of therapies that were approved by the FDA or EMA. START represents the world’s largest roster of early-phase principal investigators across its Network of clinical trial sites.

Learn more at STARTresearch.com.  

Ready to be part of a team changing the future of cancer treatment? 

Join us in our mission to conquer cancer, one clinical trial at a time. Your expertise and dedication can help us bring hope and healing to patients worldwide. Please submit your application online. 

We are an equal opportunity employer that welcomes and encourages diversity in the workplace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.