Job Description

Mentor: Chandra Sehgal, PhD

Hiring Department: Radiology

Funding Source: NIH

Number of positions: 1

U.S. Citizens and foreign nationals may apply

Project overview

The ultrasound research lab is developing hydralazine-augmented contrast ultrasound (HyCUS), a novel functional imaging technique that exploits differences in tumor versus liver vasculature to improve early detection of hepatocellular carcinoma (HCC), the fastest-growing cause of cancer death in the U.S. Our preliminary data show HyCUS more than triples lesion visibility compared to standard B-mode and contrast-enhanced ultrasound, and detects small HCC lesions missed entirely by current clinical methods. We are seeking a motivated postdoctoral fellow to help translate this promising discovery from bench to bedside.

Research Activity

The candidatewill lead validation studies in an autochthonous rat model of HCC with liver fibrosis, working across three interconnected aims: establishing the biological basis of HyCUS, defining an optimal hydralazine dosing regimen, and benchmarking HyCUS against existing sonographic surveillance methods. The investigator will work at the intersection of cancer biology, vascular pharmacology, and noninvasive imaging. The position provides an opportunity to shape a translational imaging technology from preclinical proof of concept toward eventual clinical application.

Qualifications

• PhD, MD/PhD, or equivalent doctoral degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Pharmacology, Imaging Sciences, or a related field.
• Background and interest in tumor biology, vascular physiology, or pharmacology
• Hands-on experience with animal models and histology is required
• Interest in contrast-enhanced ultrasound imaging
• Strong analytical and writing skills; interest in building an independent research trajectory

We will provide training in any missing technical skills for motivated candidates.

Application Instructions

To apply, please submit the following through Interfolio:

• Brief statement of your research experience and interests
• Curriculum Vitae
• Name and contact information of three references.

Equal Employment Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.