Job Description

About Signant Health
At Signant Health, we help bring life-changing treatments to patients faster. We are a global evidence generation company that supports clinical trials with smart technology, scientific expertise, and hands-on operational support — so better data leads to better decisions in healthcare. We embrace AI and advanced technologies to enhance every aspect of what we do, from data analysis to operational efficiency.
Our teams work at the intersection of science, technology, and patient experience, delivering digital solutions powered by AI innovation that make clinical trials more efficient, more accurate, and more accessible around the world. Trusted by leading pharmaceutical companies and CROs, our platforms and services support studies across more than 90 countries and have contributed to hundreds of new drug approvals.
If you are motivated by meaningful work, global impact, and innovation in clinical research and digital health — including the opportunity to work with cutting-edge AI technologies — you will find purpose and opportunity at Signant Health.

About the Role
The IT Applications Engineer is a generalist engineering and support role responsible for the day-to-day administration, configuration, troubleshooting, and continuous improvement of Signant Health's core business applications. The role carries particular depth in NetSuite, Microsoft 365, Box, and Atlassian (Jira, Jira Service Management, and Confluence), while also supporting the broader enterprise application portfolio as needed.
This is a hands-on, individual-contributor role that blends technical engineering — configuration, scripting, integrations, automations, and upgrades — with day-to-day operational support — tickets, incidents, and user requests. The IT Applications Engineer is a trusted first- and second-line point of contact for application issues, and is equally comfortable delivering enhancements and automations that improve reliability and reduce manual effort across the application landscape. Where the IT Application Operations Manager sets direction and leads the team, this role does the technical and support work directly, partnering closely with the Service Operations, Infrastructure Operations, and Security Operations teams.

What you will do
1. Application Administration & Configuration — Own day-to-day administration and configuration of NetSuite, Microsoft 365 (Exchange Online, SharePoint/OneDrive, Teams, Entra ID), Box, and Atlassian (Jira, JSM, Confluence), plus other assigned enterprise applications, including user provisioning, permissions, and platform settings.
2. Technical Support & Incident Resolution — Act as a key point of escalation for tier 2/3 application support tickets, diagnosing and resolving issues across the supported application stack and coordinating with vendors and other IT teams as needed.
3. Engineering & Customization — Build and maintain customizations to meet business requirements — including SuiteScript/SuiteFlow (NetSuite), Power Automate/Graph API automations (Microsoft 365), workflow and scripting configuration (Atlassian), and equivalent customizations for other supported applications.
4. Integrations & Automation — Develop and support integrations between applications using APIs, webhooks, and low-code/iPaaS tooling, building automations that reduce manual effort and improve reliability.
5. Change, Release & Patch Management — Plan, test, and execute upgrades, patches, and configuration changes across supported applications, minimizing disruption to the business.
6. Security & Compliance — Apply access control, licensing, and data-handling practices aligned with company security policy and relevant regulatory and quality requirements.
7. Monitoring & Continuous Improvement — Monitor application health, usage, and performance; proactively identify issues and recommend and implement improvements.
8. Vendor & Stakeholder Coordination — Liaise with software vendors and business stakeholders on support cases, licensing, and roadmap requests for supported platforms.
9. Documentation & Knowledge Sharing — Maintain runbooks, configuration standards, and knowledge base articles; participate in knowledge transfer and cross-training to build coverage across the application portfolio.
10. AI & Automation Adoption — Identify and pilot opportunities to apply AI-assisted tooling, agents, and low-code automation to improve support efficiency and business workflows.
11. Roadmap Support — Contribute to application-specific roadmaps for releases, improvements, and vendor-provided enhancements, in partnership with the IT Application Operations Manager.

Preferred Qualifications
1. NetSuite — Administration and configuration; SuiteScript 2.x and SuiteFlow; saved searches/SuiteAnalytics; SuiteTalk and REST API integrations.
2. Microsoft 365 — Administration of Exchange Online, SharePoint/OneDrive, Teams, and Entra ID (Azure AD); familiarity with Intune and the Power Platform (Power Automate, Power Apps).
3. Box — Content management administration, permissions and governance, and API-based integrations.
4. Atlassian — Administration and configuration of Jira, Jira Service Management, and Confluence, including workflow design and scripting (e.g., ScriptRunner).
5. APIs & Integrations — Working knowledge of REST APIs, webhooks, and low-code/iPaaS tools (e.g., Power Automate, N8N, Boomi) for connecting applications.
6. Scripting & Automation — Proficiency in at least one scripting language (JavaScript, PowerShell, or Python) for customization, troubleshooting, and automation.
7. Application Lifecycle Management — Experience with patching, upgrades, testing, and change management for SaaS/cloud and on-premise applications.
8. Security & Compliance Awareness — Understanding of access management, data protection, and relevant compliance frameworks (e.g., SOC 2, ISO 27001, and GxP where applicable).
9. ITSM & Monitoring Tools — Familiarity with ticketing/ITSM tooling (e.g., Jira Service Management) and application monitoring/observability tools.

Decision Making and Influence
1. Clear and effective communication with both technical and non-technical stakeholders.
2. Strong troubleshooting and root-cause analysis skills.
3. Good organizational and time-management skills across competing priorities.
4. Ability to document clearly and concisely for varied audiences.
5. Adaptability and resilience amid changing priorities and technologies.
6. Effective cross-team collaboration with Infrastructure, Security, Automation, and Business Analyst teams.

Desired Qualifications
1. Hands-on, detail-oriented problem solver who takes ownership of issues through to resolution.
2. Strong technical curiosity and comfort learning new platforms and technologies quickly.
3. Customer-service mindset, balancing user needs with operational and security requirements.
4. Self-motivated, able to manage multiple applications and competing priorities simultaneously.
5. Collaborative team player who shares knowledge and supports colleagues across time zones.
6. Calm and methodical under pressure, especially during incidents or critical deployments.

Why Signant Health?
At Signant Health, your work has real impact. Everything we build, support, and deliver helps advance clinical research and bring new treatments to patients faster — improving lives around the world. Our teams combine science, technology, and operational expertise to solve complex clinical trial challenges, and every role contributes to that mission.

We offer a collaborative, global environment where you can grow your career while working alongside experts across clinical, technology, data, and operations, with opportunities to learn, take ownership, and drive meaningful innovation — not just maintain the status quo.

If you are looking for purpose-driven work, smart colleagues, and the opportunity to help shape the future of clinical research and digital health, Signant Health is the place to do it.

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At Signant Health, accepting difference isn't enough — we celebrate it, we support it, and we nurture it for the benefit of our team members, our clients, and our community. We are proud to be an equal opportunity workplace and an affirmative action employer, committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status. Prior to their start date, all candidates are required to be verified through a thorough background check and identity verification to confirm eligibility for employment.