Earli exists to make cancer a benign experience. Earli does that by turning cancers against themselves: genetically forcing them to reveal themselves early, and then kill themselves – precisely and clearly distinguishable from benign lesions at early stages. Based on original technology from Stanford’s renowned Gambhir lab, Earli designs genetic constructs that are injected intravenously that turn cancer cells against themselves. These programmable synthetic promoter-reporter sequences “flip on” like light switches only in dysregulated cancer cells and turn them into "factories." The cancer is forced to produce either an epitope “docking station” for imaging agents, or a cytokine for immune system activation against the tumor. Thus, Earli’s platform enables immediate diagnosis and treatment of early cancers, rather than long-term observation that can lead to deadly metastatic recurrence.
Earli's synthetic target expression platform has evolved over five years of deep bioengineering. The system can now detect broad ranges of patient mutations, distinguish between malignant and benign lesions, and offer independence from often elusive natural biomarkers.
Who You Are
The Position
Earli is currently seeking a Head of Translational Biology to oversee and lead the translational/in vivo biology group. The successful candidate will have a proven track record of successfully initiating and managing pharmacology and translational science projects across oncology indications from Discovery through IND enabling studies. She/he will be responsible for working with the existing scientific leadership for the design and planning of in vivo preclinical studies to characterize the efficacy, PK/PD and safety properties of Earli’s proprietary compounds . This position will report to the Chief Scientific Officer.
Primary Responsibilities
Education Requirements:
Required Experience, Knowledge and Skills
If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.
We look forward to hearing from you!
Earli mission is to make cancer a benign experience by turning cancer against itself.
Earli creates genetic constructs that turn on only in cancer cells and then re-program the cancer cells to produce their own therapies, to kill themselves.
Earli has been funded by Andreessen Horowitz's a16z Bio+Health Fund, Khosla Ventures, Perceptive Advisors, Sands Capital, Marc Benioff, Menlo Ventures, Accenture Ventures, Han River Partners (S Korea). Earli is based in Redwood City, California.
For decades, the vision has been dreamed about to one day “program disease cells to kill or cure themselves.” If disease cells could be taken control of, they could be forced to run “injected biologic programs” to attack themselves or activate the body’s immune system to fight the disease. Standing in the way is a fundamental unsolved questions in medicine: how to correctly distinguish healthy cells from disease cells. For cancer, many attempts have been made to “kill the bad cells while not killing the good ones.” The conventional approaches are still crude; they attack both cancers and patients, or don't produce any response at all.
Earli turns the approach to targeting cancer cells on its head. Based on original research at Stanford University and subsequent 7 years of research at Earli, the company has built programmable genetic constructs that can infiltrate any cells but use conditional logic inside the cell nucleus to determine if a cell is a cancer cell, or not. The construct switches on only in cancer cells, then forcing them to become "factories" that produce encoded proteins that activate the immune system to attack and ultimately kill the cancer. In essence, the cancer cells are forced to produce their own therapies.
