Job Description

/ Purpose

As Vertex’sUSportfolio and pipeline expand, the Executive Director,USCommercial Technology is the senior technology leader accountable for end‑to‑end technology partnership, delivery outcomes, and operational performance forUSCommercial priorities across multiple business units and horizontal capabilities. This role serves as the single, accountable technology point of contact for the SVP,USCommercial leadershipandrepresentsDTEfunction acrossUScommercialization planning, governance, and execution. The role leads a team of senior technologyand AIleaders and orchestrates shared/platformteams todeliver measurable improvements in customer engagement, go‑to‑market effectiveness, patient services and contact center experience, operational excellence, and compliant use of data and AI in a regulated environment.

Organization Scale

• People'sleadership scope: ~23 employees (direct and indirect).

• Financial scope: ~$65M annual budget responsibility (operatingand/or vendor/program spend within remit).

Direct Reports / Scope (2026 design)

• Senior Directors leadingUStechnology partnership and delivery for:

• (1) Pain,CF,Market Access & US Commercial Operations;

• (2) Kidney,andPatient ServicesProgram; and

• (3) Heme/T1D,Cell and Gene Therapies (CGT) commercialization technology.

• Matrixedpartnershipwith global platformleadersfor CRM/digital engagement, customer engagement platforms, and AI product management to ensureUSrequirements, governance, and adoption are delivered.

Key Responsibilities

Executive Business Partnership & Stakeholder Leadership

• Serve as senior technology advisor toSVP of US commercial andUSCommercial leadershipteam;anticipateneeds, shape demand, and influence business decisions through clear, evidence‑based recommendations.

• Deliver thought leadership and guidance through the US Commercial AI Transformation

• Represent DTEas the senior technology leader forUSCommercialforums andensure alignment across Commercial, Medical, Legal/Compliance, Privacy, Security, Data Governance, and Finance partners.

• Communicate complex technology, data, and AI topics in crisp business terms; escalate risks and decisions with clear options.

USCommercial Technology Strategy

• Define and continuously refine theUSCommercial Technology strategy and multi‑yearinvestmentroadmap aligned toUScommercial goals and the broader Technologyand AIvision.

• Translate strategy into an integrated portfolio across business capabilities (BU partnership, patient services, market access/contracting, field excellence) and enabling technology (data/analytics, AI adoption, integration, quality/compliance).

• Establish the operating model and decision rights forUSCommercial Technology, clarifying what is owned within theteamvs. what is delivered via shared/global platform teams.

Portfolio Governance, Value Delivery & Operational Excellence

• Own prioritization, delivery governance, and value realization for theUSCommercial Technology portfolio; ensure transparent tradeoffs, disciplined execution, and measurable outcomes.

• Ensure reliable run performance for business‑critical systems and services within scope, including incident, problem, change, and release management expectationsappropriate forregulated commercial operations.

• Establish OKRs and value metrics tied to commercial outcomes (e.g., customer engagement effectiveness, cycle time, productivity, quality, and risk reduction), and report progress to senior business and technology leadership.

Platform Enablement & Cross‑teamIntegration

• DriveUSrequirements and adoption for shared/global platforms (e.g., CRM and digital engagement,Martech, customer engagement platforms) through tight partnership with platform owners and architecture leaders.

• EnsureUSCommercial capabilities are integrated end‑to‑end (data flows, identity/access, content, contracting, patient services) and that solutions are interoperable and scalable across BUs.

• Lead vendor strategy and buy‑vs‑build decisions within scope; rationalize and manage vendor performance in partnership with procurement and platform owners.

AIStrategy andAdoption

• Partner with AI Product Management and data/analytics leaders toidentify, prioritize, and scale the highest‑valueUScommercial AI and analytics use cases (e.g., field force excellence, content lifecycle, contracting and deal enablement, patient services automation).

• Ensure responsible AI practices: promotional and regulatory compliance, privacy/security guardrails, model risk management, andappropriate human‑in‑the‑loopcontrols.

Financial Stewardship & Vendor Management

• Own budget planning, forecasting, and ongoing financial stewardship across the ~$65M spend in scope, ensuring disciplined investment decisions and clear linkage to value and risk reduction.

• Drive cost transparency and ROI-based decision-making across programs and vendors; partner with Finance and Strategic Sourcing on contracts, renewals, and vendor performance management.

Risk Management, Compliance & Controls

• Ensure systems and solutions within scope meet Vertex policies and applicable global/local regulations related to privacy, security, promotional compliance, and data protection.

• Own third‑party risk management expectations for vendors in scope; ensure business continuity and resilience planning is in place for critical services.

• Partner with Quality/Regulatory, Security, Privacy, and Legal/Compliance to embed controls and audit readiness into delivery and operations.

People Leadership, Talent & Culture

• Lead, develop, andretaina high‑performing, inclusive leadership team; build succession depth and strengthen capability in product, data, and AI delivery.

• Mature ways of working andcoachleaders on outcomes‑based prioritization, accountability, and continuous improvement.

Minimum Qualifications

• 15+ years of progressive experience in technology, digital, data, or analytics roles, including substantial experience leading commercial‑facing technology organizations within life sciences or similarly regulated industries.

• 7+ years leading leaders (e.g., Directors/Senior Directors) with accountability for multi‑portfolio delivery and operations.

• Deep Life Sciences Commercial domain and business processexpertisealong with working knowledge of major commercial technology software platforms (e.g.Veeva, Salesforce,Snowflake,PowerBI,Model N)

• Demonstrated success delivering business outcomes through commercial platforms and capabilities (e.g., CRM/digital engagement, market access/contracting enablement, patient services/contact center, analytics) and scaling modern data/AI solutions responsibly.

• Ability to influence senior executives and governance bodies; exceptional executive communication skills.

• Strong working knowledge of security, privacy, data governance, and regulatory requirements relevant to commercial operations.

• Demonstratedfinancial managementexperience (budget ownership, vendor portfolio oversight,forecasting,and value tracking).

Pay Range:

$262,400 - $393,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com