Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking an Executive Director, Translational and Clinical Informatics to lead and grow the informatics function supporting Translational Research, preclinical development and clinical data science. You will oversee strategy, execution, and delivery of informatics solutions that enable scientific insight, accelerate timelines, and ensure high-quality data and analytical results from research into clinical execution.

Key responsibilities include:

• Own the informatics strategy and portfolio for Translational Science, Nonclinical Development & Clinical Pharmacology and Quantitative Sciences.

• Lead, develop and mentor a high-performing team of informatics professionals and manage external vendors and partners.

• Translate scientific and business needs into innovative and practical informatics strategies that align end-user scientists, partner informatics teams and enable rapid execution.

• Oversee the full lifecycle of informatics platforms including requirements, vendor selection, implementation, validation (where needed) and support.

• Drive adoption of modern cloud, data and AI-enabled technologies to accelerate scientific insight and decision-making.

• Serve as the primary informatics partner to senior scientific and development stakeholders.

• Ensure systems meet applicable GxP, data integrity and compliance requirements.

• Apply a holistic, enterprise view encompassing people, process, data, technology, science, compliance and finance to deliver informatics solutions that solve real business problems efficiently.

Required Skills, Experience and Education:

• BS/MS/Ph.D. in Computer Science, Software Engineering, Research Informatics, Bioinformatics, Cheminformatics, or a related field.

• Significant experience in scientific informatics or data engineering within biotech or pharmaceutical R&D, with a minimum of 18+ years of relevant experience with a Bachelor’s degree, 16+ years of relevant experience with a Master’s degree or 13+ years of relevant experience with a Doctoral degree.

• Demonstrated success building, leading and scaling informatics organizations and managing strategic vendor partnerships.

• Deep understanding of drug development across translational science, biomarkers, nonclinical development, clinical pharmacology, preclinical safety and clinical data management.

• Experience deploying and managing on-prem/cloud hybrid informatics solutions in AWS or Azure.

• Strong understanding of relational databases and data lakehouse platforms such as Databricks.

• Demonstrated success owning the end-to-end lifecycle of scientific informatics platforms, from requirements gathering to build/buy to implementation and long-term support.

• Experience developing AI or AI-enabling applications supporting drug development.

• Strong understanding of data model design, scientific data integration and data visualization best practices.

• Experience with statistical programming languages such as SAS and R.

Preferred Skills:

• Strong understanding of translational data types such as pathology, preclinical animal models patient biomarker data.

• Working knowledge of 21 CFR Part 11, EU Annex 11, GAMP 5, and risk-based validation approaches.

• Familiarity with clinical data platforms such as CTMS, EDC, eTMF, and IRT/RTSM systems.

  #LI-Hybrid #LI-YG1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy For additional information, please contact privacy@revmed.com

Base Pay Salary Range $265,000—$331,000 USD

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Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.

If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.