Job Description

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com

Director, People and Culture Business Partner

Location: Cambridge and Watertown, MA (between two sites at least 3 days a week)

Reports To: VP, Senior People and Culture Business Partner

Who We Are

At Prime Medicine, we're not just editing genes — we're rewriting what's possible for patients living with debilitating genetic diseases. Built on the groundbreaking Prime Editing platform, a next-generation "search and replace" technology, we are on a mission to deliver potentially curative therapies to patients who have waited long enough.

Our team of scientists, engineers, and operators is intensely curious, deeply collaborative, and united by a shared belief: that the right science, paired with the right people, can change the course of disease. We move fast, think boldly, and take our work seriously — while making sure we enjoy the journey together.

This is a pivotal moment for Prime Medicine. We are focused, energized, and building toward breakthroughs that matter. If you want to do the most meaningful work of your career alongside people who feel the same, you've found your place.

The Opportunity

Prime Medicine is seeking a Director, People and Culture Business Partner — a passionate, people-first HR professional who is as comfortable shaping culture as they are rolling up their sleeves on the operational fundamentals that keep a growing biotech humming.

Reporting to the VP, Senior People and Culture Business Partner, you'll be a trusted partner to Prime's management and employees alike - someone who connects deeply with the business, champions our culture, and helps ensure our people strategy keeps pace with our science. At Prime, People & Culture is a strategic driver of our mission.

This role is for someone who works hard, has fun, and genuinely believes that great organizations are built one person, one team, and one conversation at a time.

What You'll Do

Be a Culture Champion

• Show up as the heart of our employee experience — approachable, credible, and genuinely invested in the people you work with.
• Partner with managers and employees to reinforce and evolve Prime's culture and values as the company grows.
• Support employee engagement initiatives and translate listening efforts (surveys, conversations, data) into meaningful action.
• Help to continue to make Prime the kind of place where brilliant people do their best, most fulfilling work.

Drive Talent Strategy

• Identify development opportunities that deepen our talent bench and build organizational capability for the long term.
• Support creative career pathing efforts and employee development programs that reflect Prime's startup spirit and scientific ambition.
• Serve as a true Talent Ambassador — someone employees, management, external vendors and candidates are excited to engage with.

Partner Strategically with the Business

• Partner closely with management to drive organizational effectiveness, workforce planning, and thoughtful change management.
• Translate Prime's evolving business priorities and values into people strategies that create real impact.
• Lead organizational design efforts and guide teams through change with clarity and care.
• Provide counsel that's both candid and compassionate on employee relations and management challenges.

Execute with Excellence

• Ensure flawless execution of core HR cycles: administration, compensation planning, promotions, talent mobility, headcount planning, recruitment, and workforce planning.
• Partner with Total Rewards to navigate compensation cycles effectively and equitably.
• Contribute to policy development and evolving compliance needs as Prime scales — with a pragmatic, startup-savvy lens.

What You Bring

• An advanced degree in Human Resources, Business, Life Sciences, or a related field.
• 10–12+ years of progressive HR experience, with significant HRBP experience supporting managers and employees.
• Deep experience in biotechnology, pharmaceuticals, or life sciences — you understand the cadence, culture, and complexity of science-driven organizations.
• A startup mentality with an operator's mindset: you know when to build from scratch, when to borrow a best practice, and when to just get it done.
• Demonstrated success juggling multiple priorities in a fast-moving environment without losing sight of the details or the people.
• Strong business acumen and executive presence — you influence at all levels, and people trust your judgment.
• A high tolerance for ambiguity, a bias toward action, and a track record of driving measurable outcomes.
• You work hard, have fun, and make the team around you better.

Why Prime Medicine

• Mission that matters: Every program we advance has the potential to change — or save — a life. You'll feel that every day.
• A team you'll love: brilliant, humble, fun people who take the science seriously
• A pivotal moment: Prime is a focused, forward-moving company with a clear path and bold ambitions. You'll help shape what comes next.
• Cambridge at its best: Sit at the epicenter of the world's most dynamic biotech ecosystem.
• A seat at the table: People and Culture is a strategic partner here. Your voice will be heard and your impact will be real.

Prime Medicine is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment where all employees can thrive.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range $180,000—$220,000 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.