Job Description

We are seeking a highly motivated and strategic individual for a Director of Health Economics and Outcomes Research (HEOR) role at Alkermes. This is an exciting, visible, and highly collaborative opportunity where you will play a pivotal role in executing on evidence generation plans in support of Alkermes’ most advanced pipeline program in sleep-wake disorders. You will report to and support the Head of HEOR in the delivery of research activities and development of materials to support engagements with key stakeholders, including physicians, regulatory agencies, reimbursement bodies, and patients/advocates. The ideal candidate will have a strong technical background in HEOR, excellent data science and visualization skills, great written and verbal communication skills, and a proven ability to foster and manage internal and external relationships effectively.

Alkermes has recently adopted a hybrid working environment to support and meet the needs of employees and this role will operate in a flexible environment with at least 60% of time in the office and up to 40% from home. This position is eligible for the hybrid workplace model, requiring work to be completed onsite at our Waltham, MA office at least 3 days per week. This role is not eligible for fully remote work.

This Director of HEOR role will support our alixorexton (formerly ALKS 2680) program, which is currently in Phase 2 development and preparing for Phase 3 and potential registration. In preparation for Phase 3 activities, this role will focus on delivering high-impact research and related materials to support potential registration and reimbursement.

We are seeking a candidate who will be responsible for:

• Executing on the HEOR plan for the alixorexton program, with patient populations including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH)
• Identifying and addressing evidence gaps and prioritizing real-world studies to inform treatment patterns, disease burden, patient-reported outcomes, and unmet needs
• Developing and delivering high-quality HEOR evidence and value communication strategies to support optimal access and reimbursement aligned with the alixorexton program objectives
• Gathering and synthesizing insights from payers, healthcare professional thought leaders, and HEOR experts
• Collaborating with internal teams on publication strategies to ensure that dissemination of HEOR evidence is timely and has maximum impact across our key stakeholders with presentations at conferences and peer-reviewed manuscripts
• Selecting and managing external research partners to ensure high-quality and timely study delivery

We are seeking a candidate with experience:

• Developing budget impact models (BIMs) and cost-effectiveness analyses (CEAs)
• Conducting indirect treatment comparisons (ITCs)
• Developing Academy of Managed Care Pharmacy (AMCP) Dossiers and pre-approval information exchange (PIE) slide decks
• Real-world evidence (RWE) generation such as studies of natural history, burden of illness, treatment patterns, etc. using different data sources including claims data, electronic health records (EHR), registries, chart reviews, and qualitative research

Basic Requirements:

• MA/MS degree in HEOR/related field and 8+ years of pharmaceutical industry experience in a HEOR role with direct research experience preferred; OR
• PhD/PharmD in HEOR/related field and 5+ years of similar experience noted above

Preferred Requirements:

• Strong record of high-impact publications in peer-reviewed journals
• Excellent communication, presentation, and collaboration skills across both internal and external stakeholders
• The ideal candidate will have prior experience supporting a competitive product launch
• Having prior experience in rare disease or neurological disorders, including sleep-wake disorders such as narcolepsy and idiopathic hypersomnia, is a plus but not required
• Excellent project management skills

The annual base salary for this position ranges from $240,000 to $254,000. In addition, this position is eligible for an annual performance pay bonus. Exact compensation may vary based on skills, training, knowledge, and experience. Alkermes offers a competitive benefits package. Additional details can be found on our careers website: www.alkermes.com/careers#working-here

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Why join Team Alkermes?

Alkermes applies its decades of deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. A global biopharmaceutical company, headquartered in Ireland with U.S. locations in Massachusetts and Ohio, we seek to make a meaningful difference in the way people manage their diseases. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.

We are proud to have been recognized as an employer of choice by many national organizations. In 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts’ Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine.

Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any qualified applicant or employee because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other characteristic protected by local, state or federal law. Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Alkermes is an E-Verify employer.